Projects per year
Abstract
Objectives We aimed to compare the incidence, subtypes and aetiology of stroke, and in-hospital death due to stroke, between Aboriginal and non-Aboriginal people in Central Australia, a remote region of Australia where a high proportion Aboriginal people reside (40% of the population). We hypothesised that the rates of stroke, particularly in younger adults, would be greater in the Aboriginal population, compared with the non-Aboriginal population; we aimed to elucidate causes for any identified disparities. Design A retrospective population-based study of patients hospitalised with stroke within a defined region from 1 January 2011 to 31 December 2014. Setting Alice Springs Hospital, the only neuroimaging-capable acute hospital in Central Australia, serving a network of 50 healthcare facilities covering 672 000 km 2. Participants 161 residents (63.4% Aboriginal) of the catchment area admitted to hospital with stroke. Primary and secondary outcome measures Rates of first-ever stroke, overall (all events) stroke and in-hospital death. Results Of 121 residents with first-ever stroke, 61% identified as Aboriginal. Median onset-Age (54 years) was 17 years younger in Aboriginal patients (p<0.001), and age-standardised stroke incidence was threefold that of non-Aboriginal patients (153 vs 51 per 100 000, incidence rate ratio 3.0, 95% CI 2 to 4). The rate ratios for the overall rate of stroke (first-ever and recurrent) were similar. In Aboriginal patients aged <55 years, the incidence of ischaemic stroke was 14-fold greater (95% CI 4 to 45), and intracerebral haemorrhage 19-fold greater (95% CI 3 to 142) than in non-Aboriginal patients. Crude prevalence of diabetes mellitus (70.3% vs 34.0%, p<0.001) and hypercholesterolaemia (68.9% vs 51.1%, p=0.049) was greater, and age-standardised in-hospital deaths were fivefold greater (35 vs 7 per 100 000, 95% CI 2 to 11) in Aboriginal patients than in non-Aboriginal patients. Conclusions Stroke incidence (both subtypes) and in-hospital deaths for remote Aboriginal Australians are dramatically greater than in non-Aboriginal people, especially in patients aged <55 years.
Original language | English |
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Article number | e039533 |
Number of pages | 9 |
Journal | BMJ Open |
Volume | 10 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2020 |
Keywords
- epidemiology
- Indigenous
- intracerebral haemorrhage
- ischaemic stroke
- stroke
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Synergies TO Prevent stroke – STOPstroke
Gall, S., Thrift, A., Katzenellenbogen, J., Nelson, M. R., Kleinig, T. J., Feigin, V. L., Cadilhac, D., Nedkoff, L., Kim, J. & Kilkenny, M.
1/01/20 → 31/12/24
Project: Research
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NHMRC Research Fellowship
National Health and Medical Research Council (NHMRC) (Australia)
1/01/07 → 31/12/18
Project: Research