STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol

Leeanne Mary Carey; Sheila Gillard Crewther; Olivier Salvado; Thomas Linden; Alan Connelly; William J Wilson; David William Howells; Leonid Churilov; Henry Hin Kui Ma; Tamara Tse; Stephen E Rose; Susan Palmer; Pierrick Bougeat; Bruce Charles Vivian Campbell; Soren Christensen; Stuart Lance Macaulay; Jenny Favaloro; Victoria O' Collins; Simon J McBride; Susan Bates; Elise Cowley; Helen M Dewey; Tissa Wijeratne; Richard Patrick Gerraty; Thanh G Phan; Bernard Yan; Mark W Parsons; Christopher F Bladin; Peter Alan Barber; Stephen J Read; Andrew A Wong; Andrew Lee; Timothy John Kleinig; Graeme John Hankey; David J Blacker; Romesh Markus; James M Leyden; Martin F Krause; Rohan S Grimley; Neil Mahant; Jim Jannes; Jonathan W Sturm; Stephen M Davis; Geoffrey Donnan

doi:10.1111/ijs.12190

STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol

Leeanne Mary Carey, Sheila Gillard Crewther, Olivier Salvado, Thomas Linden, Alan Connelly, William J Wilson, David William Howells, Leonid Churilov, Henry Hin Kui Ma, Tamara Tse, Stephen E Rose, Susan Palmer, Pierrick Bougeat, Bruce Charles Vivian Campbell, Soren Christensen, Stuart Lance Macaulay, Jenny Favaloro, Victoria O' Collins, Simon J McBride, Susan BatesElise Cowley, Helen M Dewey, Tissa Wijeratne, Richard Patrick Gerraty, Thanh G Phan, Bernard Yan, Mark W Parsons, Christopher F Bladin, Peter Alan Barber, Stephen J Read, Andrew A Wong, Andrew Lee, Timothy John Kleinig, Graeme John Hankey, David J Blacker, Romesh Markus, James M Leyden, Martin F Krause, Rohan S Grimley, Neil Mahant, Jim Jannes, Jonathan W Sturm, Stephen M Davis, Geoffrey Donnan

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23 Citations (Scopus)

Abstract

RATIONALE: Stroke and poststroke depression are common and have a profound and ongoing impact on an individual s quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans. AIMS: Our aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions. DESIGN: In a longitudinal cohort study of 200 stroke survivors, the START-STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24 h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3-7, three-months, and 12 months for depression and functional outcomes. A sub-group (n = 100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified. STUDY OUTCOMES: Clinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression.

Original language	English
Pages (from-to)	636 - 644
Number of pages	9
Journal	International Journal of Stroke
Volume	10
Issue number	4
DOIs	https://doi.org/10.1111/ijs.12190
Publication status	Published - 2015

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10.1111/ijs.12190

Cite this

Carey, L. M., Crewther, S. G., Salvado, O., Linden, T., Connelly, A., Wilson, W. J., Howells, D. W., Churilov, L., Ma, H. H. K., Tse, T., Rose, S. E., Palmer, S., Bougeat, P., Campbell, B. C. V., Christensen, S., Macaulay, S. L., Favaloro, J., O' Collins, V., McBride, S. J., ... Donnan, G. (2015). STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol. International Journal of Stroke, 10(4), 636 - 644. https://doi.org/10.1111/ijs.12190

@article{4fe62322291d4aaa8596604e923a954e,

title = "STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol",

abstract = "RATIONALE: Stroke and poststroke depression are common and have a profound and ongoing impact on an individual s quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans. AIMS: Our aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions. DESIGN: In a longitudinal cohort study of 200 stroke survivors, the START-STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24 h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3-7, three-months, and 12 months for depression and functional outcomes. A sub-group (n = 100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified. STUDY OUTCOMES: Clinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression.",

author = "Carey, {Leeanne Mary} and Crewther, {Sheila Gillard} and Olivier Salvado and Thomas Linden and Alan Connelly and Wilson, {William J} and Howells, {David William} and Leonid Churilov and Ma, {Henry Hin Kui} and Tamara Tse and Rose, {Stephen E} and Susan Palmer and Pierrick Bougeat and Campbell, {Bruce Charles Vivian} and Soren Christensen and Macaulay, {Stuart Lance} and Jenny Favaloro and {O' Collins}, Victoria and McBride, {Simon J} and Susan Bates and Elise Cowley and Dewey, {Helen M} and Tissa Wijeratne and Gerraty, {Richard Patrick} and Phan, {Thanh G} and Bernard Yan and Parsons, {Mark W} and Bladin, {Christopher F} and Barber, {Peter Alan} and Read, {Stephen J} and Wong, {Andrew A} and Andrew Lee and Kleinig, {Timothy John} and Hankey, {Graeme John} and Blacker, {David J} and Romesh Markus and Leyden, {James M} and Krause, {Martin F} and Grimley, {Rohan S} and Neil Mahant and Jim Jannes and Sturm, {Jonathan W} and Davis, {Stephen M} and Geoffrey Donnan",

year = "2015",

doi = "10.1111/ijs.12190",

language = "English",

volume = "10",

pages = "636 -- 644",

journal = "International Journal of Stroke",

issn = "1747-4930",

publisher = "SAGE Publications Ltd",

number = "4",

}

Carey, LM, Crewther, SG, Salvado, O, Linden, T, Connelly, A, Wilson, WJ, Howells, DW, Churilov, L, Ma, HHK, Tse, T, Rose, SE, Palmer, S, Bougeat, P, Campbell, BCV, Christensen, S, Macaulay, SL, Favaloro, J, O' Collins, V, McBride, SJ, Bates, S, Cowley, E, Dewey, HM, Wijeratne, T, Gerraty, RP , Phan, TG, Yan, B, Parsons, MW, Bladin, CF, Barber, PA, Read, SJ, Wong, AA, Lee, A, Kleinig, TJ, Hankey, GJ, Blacker, DJ, Markus, R, Leyden, JM, Krause, MF, Grimley, RS, Mahant, N, Jannes, J, Sturm, JW, Davis, SM & Donnan, G 2015, 'STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol', International Journal of Stroke, vol. 10, no. 4, pp. 636 - 644. https://doi.org/10.1111/ijs.12190

TY - JOUR

T1 - STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol

AU - Carey, Leeanne Mary

AU - Crewther, Sheila Gillard

AU - Salvado, Olivier

AU - Linden, Thomas

AU - Connelly, Alan

AU - Wilson, William J

AU - Howells, David William

AU - Churilov, Leonid

AU - Ma, Henry Hin Kui

AU - Tse, Tamara

AU - Rose, Stephen E

AU - Palmer, Susan

AU - Bougeat, Pierrick

AU - Campbell, Bruce Charles Vivian

AU - Christensen, Soren

AU - Macaulay, Stuart Lance

AU - Favaloro, Jenny

AU - O' Collins, Victoria

AU - McBride, Simon J

AU - Bates, Susan

AU - Cowley, Elise

AU - Dewey, Helen M

AU - Wijeratne, Tissa

AU - Gerraty, Richard Patrick

AU - Phan, Thanh G

AU - Yan, Bernard

AU - Parsons, Mark W

AU - Bladin, Christopher F

AU - Barber, Peter Alan

AU - Read, Stephen J

AU - Wong, Andrew A

AU - Lee, Andrew

AU - Kleinig, Timothy John

AU - Hankey, Graeme John

AU - Blacker, David J

AU - Markus, Romesh

AU - Leyden, James M

AU - Krause, Martin F

AU - Grimley, Rohan S

AU - Mahant, Neil

AU - Jannes, Jim

AU - Sturm, Jonathan W

AU - Davis, Stephen M

AU - Donnan, Geoffrey

PY - 2015

Y1 - 2015

N2 - RATIONALE: Stroke and poststroke depression are common and have a profound and ongoing impact on an individual s quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans. AIMS: Our aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions. DESIGN: In a longitudinal cohort study of 200 stroke survivors, the START-STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24 h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3-7, three-months, and 12 months for depression and functional outcomes. A sub-group (n = 100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified. STUDY OUTCOMES: Clinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression.

AB - RATIONALE: Stroke and poststroke depression are common and have a profound and ongoing impact on an individual s quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans. AIMS: Our aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions. DESIGN: In a longitudinal cohort study of 200 stroke survivors, the START-STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24 h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3-7, three-months, and 12 months for depression and functional outcomes. A sub-group (n = 100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified. STUDY OUTCOMES: Clinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression.

U2 - 10.1111/ijs.12190

DO - 10.1111/ijs.12190

M3 - Article

SN - 1747-4930

VL - 10

SP - 636

EP - 644

JO - International Journal of Stroke

JF - International Journal of Stroke

IS - 4

ER -