Striatal but not frontal cortical up-regulation of the epidermal growth factor receptor in rats exposed to immune activation in utero and cannabinoid treatment in adolescence

Rejhan Idrizi; Peter Malcolm; Cynthia Shannon Weickert; Katerina Zavitsanou; S. Sundram

doi:10.1016/j.psychres.2016.04.026

Striatal but not frontal cortical up-regulation of the epidermal growth factor receptor in rats exposed to immune activation in utero and cannabinoid treatment in adolescence

Rejhan Idrizi
, Peter Malcolm
, Cynthia Shannon Weickert
, Katerina Zavitsanou
, S. Sundram

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

In utero maternal immune activation (MIA) and cannabinoid exposure during adolescence constitute environmental risk factors for schizophrenia. We investigated these risk factors alone and in combination ("two-hit") on epidermal growth factor receptor (EGFR) and neuregulin-1 receptor (ErbB4) levels in the rat brain. EGFR but not ErbB4 receptor protein levels were significantly increased in the nucleus accumbens and striatum of "two-hit" rats only, with no changes seen at the mRNA level. These findings support region specific EGF-system dysregulation as a plausible mechanism in this animal model of schizophrenia pathogenesis.

Original language	English
Pages (from-to)	260-264
Number of pages	5
Journal	Psychiatry Research
Volume	240
DOIs	https://doi.org/10.1016/j.psychres.2016.04.026
Publication status	Published - 30 Jun 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ErbB1
Striatum
Two-hit

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10.1016/j.psychres.2016.04.026

Cite this

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title = "Striatal but not frontal cortical up-regulation of the epidermal growth factor receptor in rats exposed to immune activation in utero and cannabinoid treatment in adolescence",

abstract = "In utero maternal immune activation (MIA) and cannabinoid exposure during adolescence constitute environmental risk factors for schizophrenia. We investigated these risk factors alone and in combination ({"}two-hit{"}) on epidermal growth factor receptor (EGFR) and neuregulin-1 receptor (ErbB4) levels in the rat brain. EGFR but not ErbB4 receptor protein levels were significantly increased in the nucleus accumbens and striatum of {"}two-hit{"} rats only, with no changes seen at the mRNA level. These findings support region specific EGF-system dysregulation as a plausible mechanism in this animal model of schizophrenia pathogenesis.",

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author = "Rejhan Idrizi and Peter Malcolm and Weickert, \{Cynthia Shannon\} and Katerina Zavitsanou and S. Sundram",

year = "2016",

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day = "30",

doi = "10.1016/j.psychres.2016.04.026",

language = "English",

volume = "240",

pages = "260--264",

journal = "Psychiatry Research",

issn = "0165-1781",

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}

Striatal but not frontal cortical up-regulation of the epidermal growth factor receptor in rats exposed to immune activation in utero and cannabinoid treatment in adolescence. / Idrizi, Rejhan; Malcolm, Peter; Weickert, Cynthia Shannon et al.
In: Psychiatry Research, Vol. 240, 30.06.2016, p. 260-264.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Striatal but not frontal cortical up-regulation of the epidermal growth factor receptor in rats exposed to immune activation in utero and cannabinoid treatment in adolescence

AU - Idrizi, Rejhan

AU - Malcolm, Peter

AU - Weickert, Cynthia Shannon

AU - Zavitsanou, Katerina

AU - Sundram, S.

PY - 2016/6/30

Y1 - 2016/6/30

N2 - In utero maternal immune activation (MIA) and cannabinoid exposure during adolescence constitute environmental risk factors for schizophrenia. We investigated these risk factors alone and in combination ("two-hit") on epidermal growth factor receptor (EGFR) and neuregulin-1 receptor (ErbB4) levels in the rat brain. EGFR but not ErbB4 receptor protein levels were significantly increased in the nucleus accumbens and striatum of "two-hit" rats only, with no changes seen at the mRNA level. These findings support region specific EGF-system dysregulation as a plausible mechanism in this animal model of schizophrenia pathogenesis.

AB - In utero maternal immune activation (MIA) and cannabinoid exposure during adolescence constitute environmental risk factors for schizophrenia. We investigated these risk factors alone and in combination ("two-hit") on epidermal growth factor receptor (EGFR) and neuregulin-1 receptor (ErbB4) levels in the rat brain. EGFR but not ErbB4 receptor protein levels were significantly increased in the nucleus accumbens and striatum of "two-hit" rats only, with no changes seen at the mRNA level. These findings support region specific EGF-system dysregulation as a plausible mechanism in this animal model of schizophrenia pathogenesis.

KW - ErbB1

KW - Striatum

KW - Two-hit

UR - https://www.scopus.com/pages/publications/84966289963

U2 - 10.1016/j.psychres.2016.04.026

DO - 10.1016/j.psychres.2016.04.026

M3 - Article

AN - SCOPUS:84966289963

SN - 0165-1781

VL - 240

SP - 260

EP - 264

JO - Psychiatry Research

JF - Psychiatry Research

ER -

Striatal but not frontal cortical up-regulation of the epidermal growth factor receptor in rats exposed to immune activation in utero and cannabinoid treatment in adolescence

Abstract

UN SDGs

Keywords

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