Striatal but not frontal cortical up-regulation of the epidermal growth factor receptor in rats exposed to immune activation in utero and cannabinoid treatment in adolescence

Rejhan Idrizi, Peter Malcolm, Cynthia Shannon Weickert, Katerina Zavitsanou, S. Sundram

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

In utero maternal immune activation (MIA) and cannabinoid exposure during adolescence constitute environmental risk factors for schizophrenia. We investigated these risk factors alone and in combination ("two-hit") on epidermal growth factor receptor (EGFR) and neuregulin-1 receptor (ErbB4) levels in the rat brain. EGFR but not ErbB4 receptor protein levels were significantly increased in the nucleus accumbens and striatum of "two-hit" rats only, with no changes seen at the mRNA level. These findings support region specific EGF-system dysregulation as a plausible mechanism in this animal model of schizophrenia pathogenesis.

Original languageEnglish
Pages (from-to)260-264
Number of pages5
JournalPsychiatry Research
Volume240
DOIs
Publication statusPublished - 30 Jun 2016
Externally publishedYes

Keywords

  • ErbB1
  • Striatum
  • Two-hit

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