TY - JOUR
T1 - Stressful life events and the clinical expression of obsessive–compulsive disorder (Ocd)
T2 - An exploratory study
AU - Imthon, André Kracker
AU - Caldart, César Antônio
AU - Do Rosário, Maria Conceição
AU - Fontenelle, Leonardo F.
AU - Miguel, Euripedes Constantino
AU - Ferrão, Ygor Arzeno
N1 - Funding Information:
Acknowledgments: This research work was financially supported by Korea Ministry of Environment (MOE) as “Knowledge-based environmental service (Waste to energy recycling) Human Resource Development Project”.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - Background: In obsessive–compulsive disorder (OCD), symptom content and severity appear to fluctuate over the course of the life cycle in accordance with stressful life events. The objective of this paper was to compare OCD patients with and without reported stressful life events (SLEs) in terms of the sociodemographics of patients and the clinical characteristics of OCD. Methods: This was a cross-sectional study involving 1001 patients with OCD. Data concerning SLEs were collected via the Yale OCD Natural History Questionnaire, while for OCD symptoms, the Dimensional Yale–Brown Obsessive–Compulsive Scale was used. Results: Of the 1001 OCD patients, 605 (60.5%) reported experiencing at least one SLE in their lifetime. Self-declared nonwhite skin color (odds ratio (OR) = 1.51), the presence of a sensory phenomenon (OR = 1.47), and comorbidity with post-traumatic stress disorder (PTSD) (OR = 2.38) were some of the logistic regression variables related to the reported SLEs with relevant statistical significance and risk (i.e., OR) values. Conclusions: Our results indicate that SLEs may make Brazilian OCD patients vulnerable to the onset or exacerbation of obsessive–compulsive symptoms. The positive association of the occurrence of SLEs and sensory phenomena in this population could corroborate that environmental influences impact the neurobiology associated with OCD, and likely with other psychiatric disorders as well.
AB - Background: In obsessive–compulsive disorder (OCD), symptom content and severity appear to fluctuate over the course of the life cycle in accordance with stressful life events. The objective of this paper was to compare OCD patients with and without reported stressful life events (SLEs) in terms of the sociodemographics of patients and the clinical characteristics of OCD. Methods: This was a cross-sectional study involving 1001 patients with OCD. Data concerning SLEs were collected via the Yale OCD Natural History Questionnaire, while for OCD symptoms, the Dimensional Yale–Brown Obsessive–Compulsive Scale was used. Results: Of the 1001 OCD patients, 605 (60.5%) reported experiencing at least one SLE in their lifetime. Self-declared nonwhite skin color (odds ratio (OR) = 1.51), the presence of a sensory phenomenon (OR = 1.47), and comorbidity with post-traumatic stress disorder (PTSD) (OR = 2.38) were some of the logistic regression variables related to the reported SLEs with relevant statistical significance and risk (i.e., OR) values. Conclusions: Our results indicate that SLEs may make Brazilian OCD patients vulnerable to the onset or exacerbation of obsessive–compulsive symptoms. The positive association of the occurrence of SLEs and sensory phenomena in this population could corroborate that environmental influences impact the neurobiology associated with OCD, and likely with other psychiatric disorders as well.
KW - Obsessive–compulsive disorder
KW - Obsessive–compulsive symptoms
KW - Risk factors
KW - Stressful life events
KW - Symptom dimensions
UR - http://www.scopus.com/inward/record.url?scp=85099398413&partnerID=8YFLogxK
U2 - 10.3390/jcm9103371
DO - 10.3390/jcm9103371
M3 - Article
C2 - 33096706
AN - SCOPUS:85099398413
VL - 9
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
SN - 2077-0383
IS - 10
M1 - 3371
ER -