Stressed SIRT7: Facing a crossroad of senescence and immortality

Jun Ping Liu, Ruping Chen

Research output: Contribution to journalEditorialOtherpeer-review

8 Citations (Scopus)

Abstract

SIRT7 with coenzyme NAD catalyzes protein de-acetylation. In stress response, SIRT7 regulates protein folding in mitochondria with unknown mechanisms. Decreases in SIRT7 entrain hematopoietic stem cell senescence, but increasing SIRT7 causes elevation of hematopoietic stem cell regenerative function. We discuss the recent findings on SIRT7 and its binding proteins, NRF1 and GABPβ1, in decision making between the choices of inducing cell aging and immortality.

Original languageEnglish
Pages (from-to)567-569
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Volume42
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015

Keywords

  • Ageing
  • Cancer
  • Hematopoietic stem cells
  • Immortality
  • Longevity
  • Senescence

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