Stressed SIRT7: Facing a crossroad of senescence and immortality

Jun Ping Liu, Ruping Chen

Research output: Contribution to journalEditorialOtherpeer-review

Abstract

SIRT7 with coenzyme NAD catalyzes protein de-acetylation. In stress response, SIRT7 regulates protein folding in mitochondria with unknown mechanisms. Decreases in SIRT7 entrain hematopoietic stem cell senescence, but increasing SIRT7 causes elevation of hematopoietic stem cell regenerative function. We discuss the recent findings on SIRT7 and its binding proteins, NRF1 and GABPβ1, in decision making between the choices of inducing cell aging and immortality.

Original languageEnglish
Pages (from-to)567-569
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Volume42
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015

Keywords

  • Ageing
  • Cancer
  • Hematopoietic stem cells
  • Immortality
  • Longevity
  • Senescence

Cite this

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abstract = "SIRT7 with coenzyme NAD catalyzes protein de-acetylation. In stress response, SIRT7 regulates protein folding in mitochondria with unknown mechanisms. Decreases in SIRT7 entrain hematopoietic stem cell senescence, but increasing SIRT7 causes elevation of hematopoietic stem cell regenerative function. We discuss the recent findings on SIRT7 and its binding proteins, NRF1 and GABPβ1, in decision making between the choices of inducing cell aging and immortality.",
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Stressed SIRT7 : Facing a crossroad of senescence and immortality. / Liu, Jun Ping; Chen, Ruping.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 42, No. 6, 01.06.2015, p. 567-569.

Research output: Contribution to journalEditorialOtherpeer-review

TY - JOUR

T1 - Stressed SIRT7

T2 - Facing a crossroad of senescence and immortality

AU - Liu, Jun Ping

AU - Chen, Ruping

PY - 2015/6/1

Y1 - 2015/6/1

N2 - SIRT7 with coenzyme NAD catalyzes protein de-acetylation. In stress response, SIRT7 regulates protein folding in mitochondria with unknown mechanisms. Decreases in SIRT7 entrain hematopoietic stem cell senescence, but increasing SIRT7 causes elevation of hematopoietic stem cell regenerative function. We discuss the recent findings on SIRT7 and its binding proteins, NRF1 and GABPβ1, in decision making between the choices of inducing cell aging and immortality.

AB - SIRT7 with coenzyme NAD catalyzes protein de-acetylation. In stress response, SIRT7 regulates protein folding in mitochondria with unknown mechanisms. Decreases in SIRT7 entrain hematopoietic stem cell senescence, but increasing SIRT7 causes elevation of hematopoietic stem cell regenerative function. We discuss the recent findings on SIRT7 and its binding proteins, NRF1 and GABPβ1, in decision making between the choices of inducing cell aging and immortality.

KW - Ageing

KW - Cancer

KW - Hematopoietic stem cells

KW - Immortality

KW - Longevity

KW - Senescence

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U2 - 10.1111/1440-1681.12423

DO - 10.1111/1440-1681.12423

M3 - Editorial

VL - 42

SP - 567

EP - 569

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

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