Stress-driven lymphatic dissemination: An unanticipated consequence of communication between the sympathetic nervous system and lymphatic vasculature

Caroline P. Le, Erica K. Sloan

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


Chronic stress drives cancer progression, but the routes of metastasis are unclear. We recently demonstrated that chronic stress activates a neural-inflammatory signaling axis to remodel lymphatic vasculature and increase lymph flow. This unanticipated crosstalk between stress and the lymphatic system provides pathways of tumor cell dissemination and accelerates metastasis.

Original languageEnglish
Article numbere1177674
Number of pages3
JournalMolecular and Cellular Oncology
Issue number4
Publication statusPublished - 3 Jul 2016


  • Adrenergic
  • lymphatic
  • metastasis
  • sympathetic nervous system
  • β-blocker

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