Abstract
Chronic stress drives cancer progression, but the routes of metastasis are unclear. We recently demonstrated that chronic stress activates a neural-inflammatory signaling axis to remodel lymphatic vasculature and increase lymph flow. This unanticipated crosstalk between stress and the lymphatic system provides pathways of tumor cell dissemination and accelerates metastasis.
| Original language | English |
|---|---|
| Article number | e1177674 |
| Number of pages | 3 |
| Journal | Molecular & Cellular Oncology |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 3 Jul 2016 |
Keywords
- Adrenergic
- lymphatic
- metastasis
- sympathetic nervous system
- β-blocker
Cite this
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Stress-driven lymphatic dissemination : An unanticipated consequence of communication between the sympathetic nervous system and lymphatic vasculature. / Le, Caroline P.; Sloan, Erica K.
In: Molecular & Cellular Oncology, Vol. 3, No. 4, e1177674, 03.07.2016.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Stress-driven lymphatic dissemination
T2 - An unanticipated consequence of communication between the sympathetic nervous system and lymphatic vasculature
AU - Le, Caroline P.
AU - Sloan, Erica K.
PY - 2016/7/3
Y1 - 2016/7/3
N2 - Chronic stress drives cancer progression, but the routes of metastasis are unclear. We recently demonstrated that chronic stress activates a neural-inflammatory signaling axis to remodel lymphatic vasculature and increase lymph flow. This unanticipated crosstalk between stress and the lymphatic system provides pathways of tumor cell dissemination and accelerates metastasis.
AB - Chronic stress drives cancer progression, but the routes of metastasis are unclear. We recently demonstrated that chronic stress activates a neural-inflammatory signaling axis to remodel lymphatic vasculature and increase lymph flow. This unanticipated crosstalk between stress and the lymphatic system provides pathways of tumor cell dissemination and accelerates metastasis.
KW - Adrenergic
KW - lymphatic
KW - metastasis
KW - sympathetic nervous system
KW - β-blocker
UR - http://www.scopus.com/inward/record.url?scp=85041860525&partnerID=8YFLogxK
U2 - 10.1080/23723556.2016.1177674
DO - 10.1080/23723556.2016.1177674
M3 - Article
VL - 3
JO - Molecular & Cellular Oncology
JF - Molecular & Cellular Oncology
SN - 2372-3556
IS - 4
M1 - e1177674
ER -