Strength in numbers - An arrestin interaction code

Christopher J. Draper-Joyce, Arthur Christopoulos

Research output: Contribution to journalReview ArticleOtherpeer-review


Activation signals from GPCRs, the largest receptor family, are transmitted to heterotrimeric G proteins and arrestins, and can be differentially modulated by GPCR phosphorylation. In a recent article, available data, including multiple arrestin structures, are analyzed to decipher common and state-specific conformational changes in arrestins and how these depend on patterns of receptor phosphorylation.

Original languageEnglish
Pages (from-to)437-439
Number of pages3
JournalNature Structural & Molecular Biology
Issue number6
Publication statusPublished - 1 Jun 2018

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