TY - JOUR
T1 - Strength in numbers - An arrestin interaction code
AU - Draper-Joyce, Christopher J.
AU - Christopoulos, Arthur
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Activation signals from GPCRs, the largest receptor family, are transmitted to heterotrimeric G proteins and arrestins, and can be differentially modulated by GPCR phosphorylation. In a recent article, available data, including multiple arrestin structures, are analyzed to decipher common and state-specific conformational changes in arrestins and how these depend on patterns of receptor phosphorylation.
AB - Activation signals from GPCRs, the largest receptor family, are transmitted to heterotrimeric G proteins and arrestins, and can be differentially modulated by GPCR phosphorylation. In a recent article, available data, including multiple arrestin structures, are analyzed to decipher common and state-specific conformational changes in arrestins and how these depend on patterns of receptor phosphorylation.
UR - http://www.scopus.com/inward/record.url?scp=85048254037&partnerID=8YFLogxK
U2 - 10.1038/s41594-018-0077-x
DO - 10.1038/s41594-018-0077-x
M3 - Review Article
AN - SCOPUS:85048254037
SN - 1545-9993
VL - 25
SP - 437
EP - 439
JO - Nature Structural & Molecular Biology
JF - Nature Structural & Molecular Biology
IS - 6
ER -