Strength, corrosion resistance, and biocompatibility of ultrafine-grained Mg alloys after different modes of severe plastic deformation

S. V. Dobatkin, E. A. Lukyanova, N. S. Martynenko, N. Yu Anisimova, M. V. Kiselevskiy, M. V. Gorshenkov, N. Yu Yurchenko, George I. Raab, V. S. Yusupov, N. Birbilis, G. A. Salishchev, Y. Z. Estrin

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The effect of severe plastic deformation on the structure, mechanical properties, corrosion resistance, and biocompatibility of the WE43 (Mg-Y-Nd-Zr) alloy earmarked for applications as bioresorbable material has been studied. The alloy was deformed by rotary swaging (RS), equal channel angular pressing (ECAP), and multiaxial deformation (MAD). The microstructure examination by transmission electron microscopy showed that all SPD modes lead to the formation of ultrafine-grained structure with a structural element size of 0.5-1 μm and the Mg12Nd phase particles 0.3 μm in size. The microstructure refinement by all three treatments resulted in strengthening of the alloy. ECAP and MAD also raised ductility to up to 12-17%, while RS increased the ultimate tensile strength to up to 415 MPa. The study of the corrosion properties showed that SPD does not affect the electrochemical corrosion of the alloy. Its biocompatibility in vitro was estimated after incubation of the samples with red blood cells (hemolysis study), white blood cells (cell viability assay), and mesenchymal stromal cells (cell proliferation analysis). The biodegradation rate in fetal bovine serum was also evaluated. ECAP and MAD were found to cause some deceleration of biodegradation by slowing down the gas formation in the biological fluid and, compared to MSC, to improve the biocompatibility of the WE43 alloy.

Original languageEnglish
Title of host publication7th International Conference on Nanomaterials by Severe Plastic Deformation, NanoSPD 2017
Place of PublicationBristol UK
PublisherIOP Publishing
Number of pages8
Publication statusPublished - 8 May 2017
EventInternational Conference on Nanomaterials by Severe Plastic Deformation 2017 - Sydney, Australia
Duration: 2 Jul 20177 Jul 2017
Conference number: 7th

Publication series

NameIOP Conference Series: Materials Science and Engineering
PublisherIOP Publishing
ISSN (Print)1757-8981


ConferenceInternational Conference on Nanomaterials by Severe Plastic Deformation 2017
Abbreviated titleNanoSPD7 2017
Internet address

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