Abstract
The effect of severe plastic deformation on the structure, mechanical properties, corrosion resistance, and biocompatibility of the WE43 (Mg-Y-Nd-Zr) alloy earmarked for applications as bioresorbable material has been studied. The alloy was deformed by rotary swaging (RS), equal channel angular pressing (ECAP), and multiaxial deformation (MAD). The microstructure examination by transmission electron microscopy showed that all SPD modes lead to the formation of ultrafine-grained structure with a structural element size of 0.5-1 μm and the Mg12Nd phase particles 0.3 μm in size. The microstructure refinement by all three treatments resulted in strengthening of the alloy. ECAP and MAD also raised ductility to up to 12-17%, while RS increased the ultimate tensile strength to up to 415 MPa. The study of the corrosion properties showed that SPD does not affect the electrochemical corrosion of the alloy. Its biocompatibility in vitro was estimated after incubation of the samples with red blood cells (hemolysis study), white blood cells (cell viability assay), and mesenchymal stromal cells (cell proliferation analysis). The biodegradation rate in fetal bovine serum was also evaluated. ECAP and MAD were found to cause some deceleration of biodegradation by slowing down the gas formation in the biological fluid and, compared to MSC, to improve the biocompatibility of the WE43 alloy.
Original language | English |
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Title of host publication | 7th International Conference on Nanomaterials by Severe Plastic Deformation, NanoSPD 2017 |
Place of Publication | Bristol UK |
Publisher | IOP Publishing |
Number of pages | 8 |
DOIs | |
Publication status | Published - 8 May 2017 |
Event | International Conference on Nanomaterials by Severe Plastic Deformation 2017 - Sydney, Australia Duration: 2 Jul 2017 → 7 Jul 2017 Conference number: 7th http://www.nanospd7.com/ |
Publication series
Name | IOP Conference Series: Materials Science and Engineering |
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Publisher | IOP Publishing |
Number | 1 |
Volume | 194 |
ISSN (Print) | 1757-8981 |
Conference
Conference | International Conference on Nanomaterials by Severe Plastic Deformation 2017 |
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Abbreviated title | NanoSPD7 2017 |
Country/Territory | Australia |
City | Sydney |
Period | 2/07/17 → 7/07/17 |
Internet address |