Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task

Takahide Itokazu, Masashi Hasegawa, Rui Kimura, Hironobu Osaki, Urban Raphael Albrecht, Kazuhiro Sohya, Shubhodeep Chakrabarti, Hideaki Itoh, Tetsufumi Ito, Tatsuo K. Sato, Takashi R. Sato

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Cortical computation is distributed across multiple areas of the cortex by networks of reciprocal connectivity. However, how such connectivity contributes to the communication between the connected areas is not clear. In this study, we examine the communication between sensory and motor cortices. We develop an eye movement task in mice and combine it with optogenetic suppression and two-photon calcium imaging techniques. We identify a small region in the secondary motor cortex (MOs) that controls eye movements and reciprocally connects with a rostrolateral part of the higher visual areas (VRL/A/AL). These two regions encode both motor signals and visual information; however, the information flow between the regions depends on the direction of the connectivity: motor information is conveyed preferentially from the MOs to the VRL/A/AL, and sensory information is transferred primarily in the opposite direction. We propose that reciprocal connectivity streamlines information flow, enhancing the computational capacity of a distributed network.

Original languageEnglish
Article number338
Number of pages14
JournalNature Communications
Volume9
Issue number1
DOIs
Publication statusPublished - 23 Jan 2018
Externally publishedYes

Keywords

  • neural circuits
  • sensorimotor processing

Cite this

Itokazu, Takahide ; Hasegawa, Masashi ; Kimura, Rui ; Osaki, Hironobu ; Albrecht, Urban Raphael ; Sohya, Kazuhiro ; Chakrabarti, Shubhodeep ; Itoh, Hideaki ; Ito, Tetsufumi ; Sato, Tatsuo K. ; Sato, Takashi R. / Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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abstract = "Cortical computation is distributed across multiple areas of the cortex by networks of reciprocal connectivity. However, how such connectivity contributes to the communication between the connected areas is not clear. In this study, we examine the communication between sensory and motor cortices. We develop an eye movement task in mice and combine it with optogenetic suppression and two-photon calcium imaging techniques. We identify a small region in the secondary motor cortex (MOs) that controls eye movements and reciprocally connects with a rostrolateral part of the higher visual areas (VRL/A/AL). These two regions encode both motor signals and visual information; however, the information flow between the regions depends on the direction of the connectivity: motor information is conveyed preferentially from the MOs to the VRL/A/AL, and sensory information is transferred primarily in the opposite direction. We propose that reciprocal connectivity streamlines information flow, enhancing the computational capacity of a distributed network.",
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Itokazu, T, Hasegawa, M, Kimura, R, Osaki, H, Albrecht, UR, Sohya, K, Chakrabarti, S, Itoh, H, Ito, T, Sato, TK & Sato, TR 2018, 'Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task', Nature Communications, vol. 9, no. 1, 338. https://doi.org/10.1038/s41467-017-02501-4

Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task. / Itokazu, Takahide; Hasegawa, Masashi; Kimura, Rui; Osaki, Hironobu; Albrecht, Urban Raphael; Sohya, Kazuhiro; Chakrabarti, Shubhodeep; Itoh, Hideaki; Ito, Tetsufumi; Sato, Tatsuo K.; Sato, Takashi R.

In: Nature Communications, Vol. 9, No. 1, 338, 23.01.2018.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Itokazu, Takahide

AU - Hasegawa, Masashi

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AU - Sohya, Kazuhiro

AU - Chakrabarti, Shubhodeep

AU - Itoh, Hideaki

AU - Ito, Tetsufumi

AU - Sato, Tatsuo K.

AU - Sato, Takashi R.

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