Strategies to rescue the consequences of inducible arginase-1 deficiency in mice

Laurel L Ballantyne, Yuan Yan Sin, Tim St Amand, Joshua Si, Steven Goossens, Lieven Haenebalcke, Jody Jonathan Haigh, Lianna G Kyriakopoulou, Andreas J Schulze, Colin David Funk

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Arginase-1 catalyzes the conversion of arginine to ornithine and urea, which is the final step of the urea cycle used to remove excess ammonia from the body. Arginase-1 deficiency leads to hyperargininemia in mice and man with severe lethal consequences in the former and progressive neurological impairment to varying degrees in the latter. In a tamoxifen-induced arginase-1 deficient mouse model, mice succumb to the enzyme deficiency within 2 weeks after inducing the knockout and retain
Original languageEnglish
Article numbere0125967
Number of pages20
JournalPLoS ONE
Issue number5
Publication statusPublished - 2015

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