Abstract
Original language | English |
---|---|
Pages (from-to) | 60 - 89 |
Number of pages | 30 |
Journal | Journal of Viral Hepatitis |
Volume | 21 |
Issue number | Supplement S1 |
DOIs | |
Publication status | Published - 2014 |
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Strategies to manage hepatitis C virus (HCV) disease burden. / Wedemeyer, Heiner; Duberg, Ann Sofi; Buti, Maria Asuncion; Rosenberg, William M C; Frankova, Sona; Esmat, Gamal; Ormeci, Necati; Van Vlierberghe, H; Gschwantler, Michael; Akarca, Ulus Salih; Aleman, Soo; Balik, Ismail; Berg, T; Bihl, Florian K; Bilodeau, M; Blasco, A J; Brandao-Mello, Carlos Eduardo; Bruggmann, Philip; Calinas, Filipe; Calleja, J L; Cheinquer, Hugo; Christensen, P B; Clausen, M; Coelho, H S M; Cornberg, Markus; Cramp, Matthew E; Dore, Gregory J; Doss, Wahid H; El-Sayed, Mohammed H; Ergor, Gul; Estes, Chris; Falconer, K; Felix, J; Ferraz, M L G; Ferreira, P R; Garcia-Samaniego, Javier; Gerstoft, J; Giria, Jose A; Goncales, Fernando Lopes; Guimaraes Pessoa, M; Hezode, Christophe; Hindman, S J; Hofer, H; Husa, P; Idilman, Ramazan; Kaberg, M; Kaita, Kelly; Kautz, Achim; Kaymakoglu, Sabahattin; Krajden, Mel; Krarup, H; Laleman, Wim J; Lavanchy, D; Lazaro, P; Marinho, R T; Marotta, P; Mauss, Stefan; Mendes-Correa, Maria Cassia Jacintho; Moreno, Christophe A; Mullhaupt, B; Myers, Robert P; Nemecek, V; Ovrehus, Anne Lindebo Holm; Parkes, J; Peltekian, Kevork Minas; Ramji, Alnoor S; Razavi, Homie A; Reis, N; Roberts, Stuart Keith; Roudot-Thoraval, Francoise; Ryder, Stephen D; Sarmento-Castro, Rui; Sarrazin, Christoph M; Semela, David; Sherman, M; Shiha, Gamal Elsayed; Sperl, J; Starkel, Peter; Stauber, R E; Thompson, Alexander James V; Urbanek, P; Van Damme, P; Van Thiel, I; Vandijck, Dominique M; Vogel, W; Waked, Imam A; Weis, N; Wiegand, Johannes; Yosry, Ayman; Zekry, Amany; Negro, Francesco; Sievert, William; Gower, Erin E.
In: Journal of Viral Hepatitis, Vol. 21, No. Supplement S1, 2014, p. 60 - 89.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Strategies to manage hepatitis C virus (HCV) disease burden
AU - Wedemeyer, Heiner
AU - Duberg, Ann Sofi
AU - Buti, Maria Asuncion
AU - Rosenberg, William M C
AU - Frankova, Sona
AU - Esmat, Gamal
AU - Ormeci, Necati
AU - Van Vlierberghe, H
AU - Gschwantler, Michael
AU - Akarca, Ulus Salih
AU - Aleman, Soo
AU - Balik, Ismail
AU - Berg, T
AU - Bihl, Florian K
AU - Bilodeau, M
AU - Blasco, A J
AU - Brandao-Mello, Carlos Eduardo
AU - Bruggmann, Philip
AU - Calinas, Filipe
AU - Calleja, J L
AU - Cheinquer, Hugo
AU - Christensen, P B
AU - Clausen, M
AU - Coelho, H S M
AU - Cornberg, Markus
AU - Cramp, Matthew E
AU - Dore, Gregory J
AU - Doss, Wahid H
AU - El-Sayed, Mohammed H
AU - Ergor, Gul
AU - Estes, Chris
AU - Falconer, K
AU - Felix, J
AU - Ferraz, M L G
AU - Ferreira, P R
AU - Garcia-Samaniego, Javier
AU - Gerstoft, J
AU - Giria, Jose A
AU - Goncales, Fernando Lopes
AU - Guimaraes Pessoa, M
AU - Hezode, Christophe
AU - Hindman, S J
AU - Hofer, H
AU - Husa, P
AU - Idilman, Ramazan
AU - Kaberg, M
AU - Kaita, Kelly
AU - Kautz, Achim
AU - Kaymakoglu, Sabahattin
AU - Krajden, Mel
AU - Krarup, H
AU - Laleman, Wim J
AU - Lavanchy, D
AU - Lazaro, P
AU - Marinho, R T
AU - Marotta, P
AU - Mauss, Stefan
AU - Mendes-Correa, Maria Cassia Jacintho
AU - Moreno, Christophe A
AU - Mullhaupt, B
AU - Myers, Robert P
AU - Nemecek, V
AU - Ovrehus, Anne Lindebo Holm
AU - Parkes, J
AU - Peltekian, Kevork Minas
AU - Ramji, Alnoor S
AU - Razavi, Homie A
AU - Reis, N
AU - Roberts, Stuart Keith
AU - Roudot-Thoraval, Francoise
AU - Ryder, Stephen D
AU - Sarmento-Castro, Rui
AU - Sarrazin, Christoph M
AU - Semela, David
AU - Sherman, M
AU - Shiha, Gamal Elsayed
AU - Sperl, J
AU - Starkel, Peter
AU - Stauber, R E
AU - Thompson, Alexander James V
AU - Urbanek, P
AU - Van Damme, P
AU - Van Thiel, I
AU - Vandijck, Dominique M
AU - Vogel, W
AU - Waked, Imam A
AU - Weis, N
AU - Wiegand, Johannes
AU - Yosry, Ayman
AU - Zekry, Amany
AU - Negro, Francesco
AU - Sievert, William
AU - Gower, Erin E
PY - 2014
Y1 - 2014
N2 - The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10 , this analysis suggests it is possible to achieve elimination of HCV (defined as a >90 decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical.
AB - The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10 , this analysis suggests it is possible to achieve elimination of HCV (defined as a >90 decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical.
UR - http://onlinelibrary.wiley.com/doi/10.1111/jvh.12249/pdf
U2 - 10.1111/jvh.12249
DO - 10.1111/jvh.12249
M3 - Article
VL - 21
SP - 60
EP - 89
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
SN - 1352-0504
IS - Supplement S1
ER -