Strategies to improve post-transplant immunity

Miguel-Angel Perales, Alan M Hanash, Jarrod Andrew Dudakov, Marcel van den Brink

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Abstract

In this chapter we will discuss current and future strategies to enhance post-transplant immune deficiency. We will briefly discuss the well-known causes for this deficiency and then direct our attention toward the considerable progress in the development of strategies to enhance immune cell recovery after hematopoietic stem cell transplantation (HSCT). We will focus on three strategies that are currently in clinical trials [Interleukin-7 (IL-7), keratinocyte growth factor 1 (KGF) and sex steroid blockade] and a few selected strategies which have shown promise in preclinical studies (Figure 6.1).
Original languageEnglish
Title of host publicationImmune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation
EditorsGerard Socie, Bruce R Blazar
Place of PublicationUK
PublisherAcademic Press
Pages123 - 142
Number of pages20
Edition1st
ISBN (Print)9780124160040
DOIs
Publication statusPublished - 2013

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