In this chapter we will discuss current and future strategies to enhance post-transplant immune deficiency. We will briefly discuss the well-known causes for this deficiency and then direct our attention toward the considerable progress in the development of strategies to enhance immune cell recovery after hematopoietic stem cell transplantation (HSCT). We will focus on three strategies that are currently in clinical trials [Interleukin-7 (IL-7), keratinocyte growth factor 1 (KGF) and sex steroid blockade] and a few selected strategies which have shown promise in preclinical studies (Figure 6.1).
|Title of host publication||Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation|
|Editors||Gerard Socie, Bruce R Blazar|
|Place of Publication||UK|
|Pages||123 - 142|
|Number of pages||20|
|Publication status||Published - 2013|