Abstract
The thymus plays a critical role in maintaining immune well-being, but paradoxically undergoes progressive age-related atrophy. Many efforts have been made to deepen our understanding of its biology, with future therapies aimed at re-establishing T cell production in immunocompromised patients. This includes the elderly, and patients undergoing cytoablative treatments or chronically infected with immunotropic viruses. Here we discuss major pre-clinical approaches to thymic regeneration, as a representation of the strategies potentially able to be utilised therapeutically. We outline thymic physiology and development to assist in understanding the rationale behind each regenerative strategy - broadly, reactivation of endogenous thymic epithelial progenitor cells, de novo generation of thymic epithelium, and the facilitating effects on these of bioengineering. Continued advancement in these approaches may lead to their clinical translation for the recovery of immune competence in the aged or immune deficient, and tolerance applications in the developing field of stem cell therapeutics.
| Original language | English |
|---|---|
| Title of host publication | Synthetic Immunology |
| Editors | Takeshi Watanabe, Yousuke Takahama |
| Place of Publication | Japan |
| Publisher | Springer |
| Pages | 57-94 |
| Number of pages | 38 |
| ISBN (Electronic) | 9784431560272 |
| ISBN (Print) | 9784431560258 |
| DOIs | |
| Publication status | Published - 1 Jan 2016 |
Cite this
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Strategies for thymic regeneration : Recent advances towards clinical therapy. / Barsanti, Marco; Hun, Michael; Boyd, Richard; Chidgey, Ann.
Synthetic Immunology. ed. / Takeshi Watanabe; Yousuke Takahama. Japan : Springer, 2016. p. 57-94.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
TY - CHAP
T1 - Strategies for thymic regeneration
T2 - Recent advances towards clinical therapy
AU - Barsanti, Marco
AU - Hun, Michael
AU - Boyd, Richard
AU - Chidgey, Ann
PY - 2016/1/1
Y1 - 2016/1/1
N2 - The thymus plays a critical role in maintaining immune well-being, but paradoxically undergoes progressive age-related atrophy. Many efforts have been made to deepen our understanding of its biology, with future therapies aimed at re-establishing T cell production in immunocompromised patients. This includes the elderly, and patients undergoing cytoablative treatments or chronically infected with immunotropic viruses. Here we discuss major pre-clinical approaches to thymic regeneration, as a representation of the strategies potentially able to be utilised therapeutically. We outline thymic physiology and development to assist in understanding the rationale behind each regenerative strategy - broadly, reactivation of endogenous thymic epithelial progenitor cells, de novo generation of thymic epithelium, and the facilitating effects on these of bioengineering. Continued advancement in these approaches may lead to their clinical translation for the recovery of immune competence in the aged or immune deficient, and tolerance applications in the developing field of stem cell therapeutics.
AB - The thymus plays a critical role in maintaining immune well-being, but paradoxically undergoes progressive age-related atrophy. Many efforts have been made to deepen our understanding of its biology, with future therapies aimed at re-establishing T cell production in immunocompromised patients. This includes the elderly, and patients undergoing cytoablative treatments or chronically infected with immunotropic viruses. Here we discuss major pre-clinical approaches to thymic regeneration, as a representation of the strategies potentially able to be utilised therapeutically. We outline thymic physiology and development to assist in understanding the rationale behind each regenerative strategy - broadly, reactivation of endogenous thymic epithelial progenitor cells, de novo generation of thymic epithelium, and the facilitating effects on these of bioengineering. Continued advancement in these approaches may lead to their clinical translation for the recovery of immune competence in the aged or immune deficient, and tolerance applications in the developing field of stem cell therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85018231766&partnerID=8YFLogxK
U2 - 10.1007/978-4-431-56027-2_3
DO - 10.1007/978-4-431-56027-2_3
M3 - Chapter (Book)
SN - 9784431560258
SP - 57
EP - 94
BT - Synthetic Immunology
A2 - Watanabe, Takeshi
A2 - Takahama, Yousuke
PB - Springer
CY - Japan
ER -