Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: Pre-clinical and clinical approaches

Ann Patricia Chidgey, Natalie Louise Seach, Jarrod Andrew Dudakov, Maree Vanessa Hammett, Richard Lennox Boyd

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    23 Citations (Scopus)

    Abstract

    Poor immune recovery is characteristic of bone marrow transplantation and leads to high levels of morbidity and mortality. The primary underlying cause is a compromised thymic function, resulting from age-induced atrophy and further compounded by the damaging effects of cytoablative conditioning regimes on thymic epithelial cells (TEC). Several strategies have been proposed to enhance T cell reconstitution. Some, such as the use of single biological agents, are currently being tested in clinical trials. However, a more rational approach to immune restoration will be to leverage the evolving repertoire of new technologies. Specifically, the combined targeting of TEC, thymocytes and peripheral T cells, together with the bone marrow niches, promises a more strategic clinical therapeutic platform.
    Original languageEnglish
    Pages (from-to)457 - 477
    Number of pages21
    JournalSeminars in Immunopathology
    Volume30
    Issue number4
    Publication statusPublished - 2008

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