Strategies for designing and validating immunostimulatory siRNAs

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Abstract

Specific clinical applications of RNA interference (RNAi) can benefit from a concurrent activation of the immune system. This is the case for small interfering RNAs (siRNAs) with antitumor or antiviral activities. This chapter provides a brief overview of the strategies reported to date to design siRNAs with gene silencing and immune activating properties, as well as methods for the validation of immunostimulatory activities.
Original languageEnglish
Title of host publicationsiRNA Design
Subtitle of host publicationMethods and Protocols
EditorsDebra J. Taxman
Place of PublicationTotowa, NJ USA
PublisherHumana Press
Chapter10
Pages179-191
Number of pages13
Edition1st
ISBN (Print)9781627031189
DOIs
Publication statusPublished - 2013

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
Volume942
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

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