Strategies for designing and validating immunostimulatory siRNAs

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Abstract

Specific clinical applications of RNA interference (RNAi) can benefit from a concurrent activation of the immune system. This is the case for small interfering RNAs (siRNAs) with antitumor or antiviral activities. This chapter provides a brief overview of the strategies reported to date to design siRNAs with gene silencing and immune activating properties, as well as methods for the validation of immunostimulatory activities.
Original languageEnglish
Pages (from-to)179 - 191
Number of pages13
JournalMethods in Molecular Biology
Volume942
DOIs
Publication statusPublished - 2013

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