TY - JOUR
T1 - Strategies for designing and validating immunostimulatory siRNAs
AU - Gantier, Michael Paul Marie
PY - 2013
Y1 - 2013
N2 - Specific clinical applications of RNA interference (RNAi) can benefit from a concurrent activation of the immune system. This is the case for small interfering RNAs (siRNAs) with antitumor or antiviral activities. This chapter provides a brief overview of the strategies reported to date to design siRNAs with gene silencing and immune activating properties, as well as methods for the validation of immunostimulatory activities.
AB - Specific clinical applications of RNA interference (RNAi) can benefit from a concurrent activation of the immune system. This is the case for small interfering RNAs (siRNAs) with antitumor or antiviral activities. This chapter provides a brief overview of the strategies reported to date to design siRNAs with gene silencing and immune activating properties, as well as methods for the validation of immunostimulatory activities.
UR - http://download.springer.com/static/pdf/354/chp%253A10.1007%252F978-1-62703-119-6_10.pdf?auth66=1394935028_384e71579020cc1198c213eef85e95b5&ext=.pdf
U2 - 10.1007/978-1-62703-119-6_10
DO - 10.1007/978-1-62703-119-6_10
M3 - Article
VL - 942
SP - 179
EP - 191
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
SN - 1064-3745
ER -