Strategies for designing and validating immunostimulatory siRNAs

Michael Paul Marie Gantier

doi:10.1007/978-1-62703-119-6_10

Strategies for designing and validating immunostimulatory siRNAs

Michael Paul Marie Gantier

Hudson Institute - Centre for Cancer Research

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

5 Citations (Scopus)

Abstract

Specific clinical applications of RNA interference (RNAi) can benefit from a concurrent activation of the immune system. This is the case for small interfering RNAs (siRNAs) with antitumor or antiviral activities. This chapter provides a brief overview of the strategies reported to date to design siRNAs with gene silencing and immune activating properties, as well as methods for the validation of immunostimulatory activities.

Original language	English
Title of host publication	siRNA Design
Subtitle of host publication	Methods and Protocols
Editors	Debra J. Taxman
Place of Publication	Totowa, NJ USA
Publisher	Humana Press
Chapter	10
Pages	179-191
Number of pages	13
Edition	1st
ISBN (Print)	9781627031189
DOIs	https://doi.org/10.1007/978-1-62703-119-6_10
Publication status	Published - 2013

Publication series

Name	Methods in Molecular Biology
Publisher	Humana Press
Volume	942
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

Access to Document

10.1007/978-1-62703-119-6_10

microRNA regulation of antiviral responses
Gantier, M. (Primary Chief Investigator (PCI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/12 → 31/12/14
Project: Research
Protein recognition of small RNAs in innate immunity
Williams, B. (Primary Chief Investigator (PCI)), Wilce, M. (Chief Investigator (CI)) & Wilce, J. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/11 → 31/12/13
Project: Research

Cite this

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abstract = "Specific clinical applications of RNA interference (RNAi) can benefit from a concurrent activation of the immune system. This is the case for small interfering RNAs (siRNAs) with antitumor or antiviral activities. This chapter provides a brief overview of the strategies reported to date to design siRNAs with gene silencing and immune activating properties, as well as methods for the validation of immunostimulatory activities.",

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AB - Specific clinical applications of RNA interference (RNAi) can benefit from a concurrent activation of the immune system. This is the case for small interfering RNAs (siRNAs) with antitumor or antiviral activities. This chapter provides a brief overview of the strategies reported to date to design siRNAs with gene silencing and immune activating properties, as well as methods for the validation of immunostimulatory activities.

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Strategies for designing and validating immunostimulatory siRNAs

Abstract

Publication series

Access to Document

Projects

microRNA regulation of antiviral responses

Protein recognition of small RNAs in innate immunity

Cite this