Strategies and challenges for systematically mapping biologically significant molecular pathways regulating carcinoma epithelial-mesenchymal transition

Nur Akmarina Binti Mohd Said, Kaylene J Simpson, Elizabeth Williams

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)


Enormous progress has been made towards understanding the role of specific factors in the process of epithelial-mesen- chymal transition (EMT); however, the complex underlying pathways and the transient nature of the transition contin- ues to present significant challenges. Targeting tumour cell plasticity underpinning EMT is an attractive strategy to com- bat metastasis. Global gene expression profiling and high- content analyses are among the strategies employed to identify novel EMT regulators. In this review, we highlight several approaches to systematically interrogate key path- ways involved in EMT, with particular emphasis on the fea- tures of multiparametric, high-content imaging screening strategies that lend themselves to the systematic discovery of highly significant modulators of tumour cell plasticity.
Original languageEnglish
Pages (from-to)424 - 434
Number of pages11
JournalCells Tissues Organs
Issue number6
Publication statusPublished - 2013

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