Abstract
Enormous progress has been made towards understanding
the role of specific factors in the process of epithelial-mesen-
chymal transition (EMT); however, the complex underlying
pathways and the transient nature of the transition contin-
ues to present significant challenges. Targeting tumour cell plasticity underpinning EMT is an attractive strategy to com-
bat metastasis. Global gene expression profiling and high-
content analyses are among the strategies employed to
identify novel EMT regulators. In this review, we highlight
several approaches to systematically interrogate key path-
ways involved in EMT, with particular emphasis on the fea-
tures of multiparametric, high-content imaging screening
strategies that lend themselves to the systematic discovery
of highly significant modulators of tumour cell plasticity.
Original language | English |
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Pages (from-to) | 424 - 434 |
Number of pages | 11 |
Journal | Cells Tissues Organs |
Volume | 197 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2013 |