Stochastic lattice model for bone remodeling and aging

The remodelling process of trabecular bone inside a human vertebral body was investigated using a stochastic model in which the ability of living bone to adapt to mechanical stimuli was incorporated. The emergence of a networklike structure, similar to real trabecular bone was shown using simulations. The bone volume fraction was found to reach a steady state with time, and microstructure was found to coarsen with a typical length in the system following a power law. The coarsening of the trabecular bone, as suggested by the simulation, was found to occur as a natural aging phenomena, and not related to disease.