@article{adfae4d8868c41fd880351dc3145d176,
title = "Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans",
abstract = "The neural circuits that regulate placebo analgesia responsivity are unknown, although engagement of brainstem pain modulatory regions is likely critical. Here we show in 47 participants that differences are present in neural circuit connectivity{\textquoteright}s in placebo responders versus non-responders. We distinguish stimulus-independent and stimulus-dependent neural networks that display altered connections between the hypothalamus, anterior cingulate cortex and midbrain periaqueductal gray matter. This dual regulatory system underpins an individual{\textquoteright}s ability to mount placebo analgesia.",
author = "Crawford, {Lewis S.} and Noemi Meylakh and Macey, {Paul M.} and Macefield, {Vaughan G.} and Keay, {Kevin A.} and Henderson, {Luke A.}",
note = "Funding Information: The authors acknowledge the facilities, scientific and technical assistance from the National Imaging Facility, a National Collaborative Research Infrastructure Strategy capability, at the Melbourne Brain Center Imaging Unit, The University of Melbourne. This work was supported by the University of Melbourne, funding from the Australian National Health and Medical Research Council grant 1130280, and the NGW Macintosh memorial fund. Publisher Copyright: {\textcopyright} 2023, Crown.",
year = "2023",
month = dec,
doi = "10.1038/s42003-023-04951-7",
language = "English",
volume = "6",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "Nature Publishing Group",
number = "1",
}