Stimuli-responsive lipid-based self-assembled systems

Benjamin James Boyd, Wye Khay Fong

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

8 Citations (Scopus)

Abstract

Lipid based self assembled matrices have been proposed as novel drug delivery systems, as the phases formed by these materials have been shown to reliably encapsulate and control the release of actives. The unique nanostructures formed by many lipids are dictated by the specifi c local packing of the amphiphiles in the matrix. Lipid packing is determined by molecular geometry of the lipids, which can be reversibly or irreversibly modifi ed by changes in environmental factors such as temperature and pH. In recent times, much research has tapped into the rich vein of liquid crystalline nanostructures and their manipulations for on-demand drug release. This chapter details the use of self assembled systems in drug delivery with a particular focus on how they have been rendered stimuli responsive and their potential uses in pharmaceutical therapies.
Original languageEnglish
Title of host publicationSelf-Assembled Supramolecular Architectures: Lyotropic Liquid Crystals
EditorsNissim Garti, Ponisseril Somasundaran, Raffaele Mezzenga
Place of PublicationHoboken New Jersey
PublisherWiley-Blackwell
Pages257 - 288
Number of pages32
ISBN (Print)978-047028175-8
DOIs
Publication statusPublished - 2012

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