Lipid based self assembled matrices have been proposed as novel drug delivery systems, as the phases formed by these materials have been shown to reliably encapsulate and control the release of actives. The unique nanostructures formed by many lipids are dictated by the specifi c local packing of the amphiphiles in the matrix. Lipid packing is determined by molecular geometry of the lipids, which can be reversibly or irreversibly modifi ed by changes in environmental factors such as temperature and pH. In recent times, much research has tapped into the rich vein of liquid crystalline nanostructures and their manipulations for on-demand drug release. This chapter details the use of self assembled systems in drug delivery with a particular focus on how they have been rendered stimuli responsive and their potential uses in pharmaceutical therapies.
|Title of host publication||Self-Assembled Supramolecular Architectures: Lyotropic Liquid Crystals|
|Editors||Nissim Garti, Ponisseril Somasundaran, Raffaele Mezzenga|
|Place of Publication||Hoboken New Jersey|
|Pages||257 - 288|
|Number of pages||32|
|Publication status||Published - 2012|