Stimulation of erythropoietin release by hypoxia and hypoxemia: similar but different

Chang Joon Lee; David W. Smith; Bruce S. Gardiner; Roger G. Evans

doi:10.1016/j.kint.2018.09.025

Stimulation of erythropoietin release by hypoxia and hypoxemia: similar but different

Chang Joon Lee, David W. Smith, Bruce S. Gardiner, Roger G. Evans

Research output: Contribution to journal › Comment / Debate › Other › peer-review

4 Citations (Scopus)

Abstract

Erythropoietin is released from the kidney in response to tissue hypoxia. Montero and Lundby found that increases in plasma erythropoietin induced by reducing arterial oxygen content in healthy humans were independent of arterial oxygen tension. Their observations accord with the established physiology of kidney oxygenation and can be predicted by a computational model of renal oxygen transport. However, model simulations indicate that the interpretation implicit in the title of their paper may be an oversimplification.

Original language	English
Pages (from-to)	23-25
Number of pages	3
Journal	Kidney International
Volume	95
Issue number	1
DOIs	https://doi.org/10.1016/j.kint.2018.09.025
Publication status	Published - 1 Jan 2019

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abstract = "Erythropoietin is released from the kidney in response to tissue hypoxia. Montero and Lundby found that increases in plasma erythropoietin induced by reducing arterial oxygen content in healthy humans were independent of arterial oxygen tension. Their observations accord with the established physiology of kidney oxygenation and can be predicted by a computational model of renal oxygen transport. However, model simulations indicate that the interpretation implicit in the title of their paper may be an oversimplification.",

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AU - Lee, Chang Joon

AU - Smith, David W.

AU - Gardiner, Bruce S.

AU - Evans, Roger G.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Erythropoietin is released from the kidney in response to tissue hypoxia. Montero and Lundby found that increases in plasma erythropoietin induced by reducing arterial oxygen content in healthy humans were independent of arterial oxygen tension. Their observations accord with the established physiology of kidney oxygenation and can be predicted by a computational model of renal oxygen transport. However, model simulations indicate that the interpretation implicit in the title of their paper may be an oversimplification.

AB - Erythropoietin is released from the kidney in response to tissue hypoxia. Montero and Lundby found that increases in plasma erythropoietin induced by reducing arterial oxygen content in healthy humans were independent of arterial oxygen tension. Their observations accord with the established physiology of kidney oxygenation and can be predicted by a computational model of renal oxygen transport. However, model simulations indicate that the interpretation implicit in the title of their paper may be an oversimplification.

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DO - 10.1016/j.kint.2018.09.025

M3 - Comment / Debate

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AN - SCOPUS:85058525154

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JO - Kidney International

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ER -

Stimulation of erythropoietin release by hypoxia and hypoxemia: similar but different

Abstract

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