Steric stabilizers for cubic phase lyotropic liquid crystal nanodispersions (cubosomes)

Josephine Y T Chong, Xavier Mulet, Ben J Boyd, Calum J Drummond

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

39 Citations (Scopus)

Abstract

Lyotropic liquid crystalline nanostructured particles, such as cubosomes, have grown in popularity as drug delivery systems in the last few years. These systems require steric stabilizers to maintain colloidal stability in an aqueous medium, with Pluronic®F127, a block copolymer, being the most commonly employed stabilizer. However, in recent years, alternative, more effective stabilizers, as well as rationally designed systems with opportunities for further biofunctionalization have been reported. The purpose of this chapter is to collate and collectively interpret studies in the field of steric stabilization of this important emerging class of nanoparticles for drug and medical imaging agent delivery.
Original languageEnglish
Title of host publicationAdvances in Planar Lipid Bilayers and Liposomes
EditorsAles Iglic, Chandrashekhar V Kulkarni, Michael Rappolt
Place of PublicationWaltham MA USA
PublisherElsevier
Pages131-187
Number of pages57
Edition1
ISBN (Print)9780128021163
DOIs
Publication statusPublished - 2015

Keywords

  • Bicontinuous cubic
  • Colloidal
  • Cubosome
  • Lytropic liquid crystal
  • Nanodispersion
  • Self-assembly
  • Stabilizer
  • Steric stabilization

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