Stereotactic ablative body radiation therapy for primary kidney cancer: a 3-dimensional conformal technique associated with low rates of early toxicity

Daniel Josef Pham; Ann Thompson; Tomas Kron; Farshad Foroudi; Michal E Schneider; Thomas Devereux; Andrew Lim; Shankar Siva

doi:10.1016/j.ijrobp.2014.07.043

Stereotactic ablative body radiation therapy for primary kidney cancer: a 3-dimensional conformal technique associated with low rates of early toxicity

Daniel Josef Pham, Ann Thompson, Tomas Kron, Farshad Foroudi, Michal E Schneider, Thomas Devereux, Andrew Lim, Shankar Siva

Medical Imaging & Radiation Sciences

Research output: Contribution to journal › Article › Research › peer-review

55 Citations (Scopus)

Abstract

PURPOSE: To describe our 3-dimensional conformal planning approaches and report early toxicities with stereotactic body radiation therapy for the management of primary renal cell carcinoma. METHODS AND MATERIALS: This is an analysis of a phase 1 trial of stereotactic body radiation therapy for primary inoperable renal cell carcinoma. A dose of 42 Gy/3 fractions was prescribed to targets >/=5 cm, whereas for 100 cm(3) the median beam number used was 10 (4 noncoplanar) for an average R50 value of 4.3. The R50 was inversely proportional to decreasing PTV volume (r=-0.62, P=.003) and increasing total beams used (r=-0.51, P=.022). Twelve of 20 patients (60 ) suffered grade

Original language	English
Pages (from-to)	1061 - 1068
Number of pages	8
Journal	International Journal of Radiation Oncology Biology Physics
Volume	90
Issue number	5
DOIs	https://doi.org/10.1016/j.ijrobp.2014.07.043
Publication status	Published - 2014

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10.1016/j.ijrobp.2014.07.043

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Pham, D. J., Thompson, A., Kron, T., Foroudi, F., Schneider, M. E., Devereux, T., Lim, A., & Siva, S. (2014). Stereotactic ablative body radiation therapy for primary kidney cancer: a 3-dimensional conformal technique associated with low rates of early toxicity. International Journal of Radiation Oncology Biology Physics, 90(5), 1061 - 1068. https://doi.org/10.1016/j.ijrobp.2014.07.043

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title = "Stereotactic ablative body radiation therapy for primary kidney cancer: a 3-dimensional conformal technique associated with low rates of early toxicity",

abstract = "PURPOSE: To describe our 3-dimensional conformal planning approaches and report early toxicities with stereotactic body radiation therapy for the management of primary renal cell carcinoma. METHODS AND MATERIALS: This is an analysis of a phase 1 trial of stereotactic body radiation therapy for primary inoperable renal cell carcinoma. A dose of 42 Gy/3 fractions was prescribed to targets >/=5 cm, whereas for 100 cm(3) the median beam number used was 10 (4 noncoplanar) for an average R50 value of 4.3. The R50 was inversely proportional to decreasing PTV volume (r=-0.62, P=.003) and increasing total beams used (r=-0.51, P=.022). Twelve of 20 patients (60 ) suffered grade",

author = "Pham, {Daniel Josef} and Ann Thompson and Tomas Kron and Farshad Foroudi and Schneider, {Michal E} and Thomas Devereux and Andrew Lim and Shankar Siva",

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language = "English",

volume = "90",

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Pham, DJ, Thompson, A, Kron, T, Foroudi, F, Schneider, ME, Devereux, T, Lim, A & Siva, S 2014, 'Stereotactic ablative body radiation therapy for primary kidney cancer: a 3-dimensional conformal technique associated with low rates of early toxicity', International Journal of Radiation Oncology Biology Physics, vol. 90, no. 5, pp. 1061 - 1068. https://doi.org/10.1016/j.ijrobp.2014.07.043

Stereotactic ablative body radiation therapy for primary kidney cancer: a 3-dimensional conformal technique associated with low rates of early toxicity. / Pham, Daniel Josef; Thompson, Ann; Kron, Tomas et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 90, No. 5, 2014, p. 1061 - 1068.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - Stereotactic ablative body radiation therapy for primary kidney cancer: a 3-dimensional conformal technique associated with low rates of early toxicity

AU - Pham, Daniel Josef

AU - Thompson, Ann

AU - Kron, Tomas

AU - Foroudi, Farshad

AU - Schneider, Michal E

AU - Devereux, Thomas

AU - Lim, Andrew

AU - Siva, Shankar

PY - 2014

Y1 - 2014

N2 - PURPOSE: To describe our 3-dimensional conformal planning approaches and report early toxicities with stereotactic body radiation therapy for the management of primary renal cell carcinoma. METHODS AND MATERIALS: This is an analysis of a phase 1 trial of stereotactic body radiation therapy for primary inoperable renal cell carcinoma. A dose of 42 Gy/3 fractions was prescribed to targets >/=5 cm, whereas for 100 cm(3) the median beam number used was 10 (4 noncoplanar) for an average R50 value of 4.3. The R50 was inversely proportional to decreasing PTV volume (r=-0.62, P=.003) and increasing total beams used (r=-0.51, P=.022). Twelve of 20 patients (60 ) suffered grade

AB - PURPOSE: To describe our 3-dimensional conformal planning approaches and report early toxicities with stereotactic body radiation therapy for the management of primary renal cell carcinoma. METHODS AND MATERIALS: This is an analysis of a phase 1 trial of stereotactic body radiation therapy for primary inoperable renal cell carcinoma. A dose of 42 Gy/3 fractions was prescribed to targets >/=5 cm, whereas for 100 cm(3) the median beam number used was 10 (4 noncoplanar) for an average R50 value of 4.3. The R50 was inversely proportional to decreasing PTV volume (r=-0.62, P=.003) and increasing total beams used (r=-0.51, P=.022). Twelve of 20 patients (60 ) suffered grade

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DO - 10.1016/j.ijrobp.2014.07.043

M3 - Article

SN - 0360-3016

VL - 90

SP - 1061

EP - 1068

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 5

ER -

Stereotactic ablative body radiation therapy for primary kidney cancer: a 3-dimensional conformal technique associated with low rates of early toxicity

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