Stereoselective synthesis and application of β-amino ketones

Nghi H. Nguyen, Andrew B Hughes, Brad E Sleebs

Research output: Contribution to journalReview ArticleResearchpeer-review

22 Citations (Scopus)

Abstract

β-Amino ketones are of increasing interest owing to their utility as important synthetic precursors in the synthesis of bioactive molecules and natural products. As a result numerous syntheses of β-amino ketones have emerged in recent years. Of particular significance are those methods that allow access to stereopure β-amino ketones. This review highlights recent advances in stereoselective syntheses of β-amino ketones and also illustrates the importance of β-amino ketones as useful synthons.

Original languageEnglish
Pages (from-to)260-289
Number of pages30
JournalCurrent Organic Chemistry
Volume18
Issue number2
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • β-amino ketones
  • Amino alcohols
  • Conjugate additions
  • Diastereoselectivity
  • Enantioselectivity
  • Mannich addition

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