Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins

W. Roy Jackson, Howard A. Jacobs, Barry R. Matthews, Gamini S. Jayatilake, Keith G. Watson

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Abstract

Ephedrine and related optically active β-aminoalcohols can be prepared by zinc borohydride reduction of aryl O-protected magnesium imines and aryl α-hydroxyimines which in turn are readily available from optically active cyanohydrins.

Original languageEnglish
Pages (from-to)1447-1450
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number10
DOIs
Publication statusPublished - 1 Jan 1990

Cite this

Roy Jackson, W. ; Jacobs, Howard A. ; Matthews, Barry R. ; Jayatilake, Gamini S. ; Watson, Keith G. / Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins. In: Tetrahedron Letters. 1990 ; Vol. 31, No. 10. pp. 1447-1450.
@article{c51ba7a965764a3199e0c89047d6fd79,
title = "Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins",
abstract = "Ephedrine and related optically active β-aminoalcohols can be prepared by zinc borohydride reduction of aryl O-protected magnesium imines and aryl α-hydroxyimines which in turn are readily available from optically active cyanohydrins.",
author = "{Roy Jackson}, W. and Jacobs, {Howard A.} and Matthews, {Barry R.} and Jayatilake, {Gamini S.} and Watson, {Keith G.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/S0040-4039(00)88829-2",
language = "English",
volume = "31",
pages = "1447--1450",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier",
number = "10",

}

Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins. / Roy Jackson, W.; Jacobs, Howard A.; Matthews, Barry R.; Jayatilake, Gamini S.; Watson, Keith G.

In: Tetrahedron Letters, Vol. 31, No. 10, 01.01.1990, p. 1447-1450.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins

AU - Roy Jackson, W.

AU - Jacobs, Howard A.

AU - Matthews, Barry R.

AU - Jayatilake, Gamini S.

AU - Watson, Keith G.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Ephedrine and related optically active β-aminoalcohols can be prepared by zinc borohydride reduction of aryl O-protected magnesium imines and aryl α-hydroxyimines which in turn are readily available from optically active cyanohydrins.

AB - Ephedrine and related optically active β-aminoalcohols can be prepared by zinc borohydride reduction of aryl O-protected magnesium imines and aryl α-hydroxyimines which in turn are readily available from optically active cyanohydrins.

UR - http://www.scopus.com/inward/record.url?scp=0025218064&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)88829-2

DO - 10.1016/S0040-4039(00)88829-2

M3 - Article

VL - 31

SP - 1447

EP - 1450

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 10

ER -