Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins

W. Roy Jackson, Howard A. Jacobs, Barry R. Matthews, Gamini S. Jayatilake, Keith G. Watson

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87 Citations (Scopus)

Abstract

Ephedrine and related optically active β-aminoalcohols can be prepared by zinc borohydride reduction of aryl O-protected magnesium imines and aryl α-hydroxyimines which in turn are readily available from optically active cyanohydrins.

Original languageEnglish
Pages (from-to)1447-1450
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number10
DOIs
Publication statusPublished - 1 Jan 1990

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