Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins

W. Roy Jackson; Howard A. Jacobs; Barry R. Matthews; Gamini S. Jayatilake; Keith G. Watson

doi:10.1016/S0040-4039(00)88829-2

Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins

W. Roy Jackson, Howard A. Jacobs, Barry R. Matthews, Gamini S. Jayatilake, Keith G. Watson

School of Chemistry

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Abstract

Ephedrine and related optically active β-aminoalcohols can be prepared by zinc borohydride reduction of aryl O-protected magnesium imines and aryl α-hydroxyimines which in turn are readily available from optically active cyanohydrins.

Original language	English
Pages (from-to)	1447-1450
Number of pages	4
Journal	Tetrahedron Letters
Volume	31
Issue number	10
DOIs	https://doi.org/10.1016/S0040-4039(00)88829-2
Publication status	Published - 1 Jan 1990

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title = "Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins",

abstract = "Ephedrine and related optically active β-aminoalcohols can be prepared by zinc borohydride reduction of aryl O-protected magnesium imines and aryl α-hydroxyimines which in turn are readily available from optically active cyanohydrins.",

author = "{Roy Jackson}, W. and Jacobs, {Howard A.} and Matthews, {Barry R.} and Jayatilake, {Gamini S.} and Watson, {Keith G.}",

year = "1990",

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T1 - Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins

AU - Roy Jackson, W.

AU - Jacobs, Howard A.

AU - Matthews, Barry R.

AU - Jayatilake, Gamini S.

AU - Watson, Keith G.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Ephedrine and related optically active β-aminoalcohols can be prepared by zinc borohydride reduction of aryl O-protected magnesium imines and aryl α-hydroxyimines which in turn are readily available from optically active cyanohydrins.

AB - Ephedrine and related optically active β-aminoalcohols can be prepared by zinc borohydride reduction of aryl O-protected magnesium imines and aryl α-hydroxyimines which in turn are readily available from optically active cyanohydrins.

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U2 - 10.1016/S0040-4039(00)88829-2

DO - 10.1016/S0040-4039(00)88829-2

M3 - Article

AN - SCOPUS:0025218064

SN - 0040-4039

VL - 31

SP - 1447

EP - 1450

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 10

ER -

Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins

Abstract

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