Stem cells in prostate cancer: Treating the root of the problem

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Prostate cancer is a hormone-dependent, epithelial-derived tumor, resulting from uncontrolled growth of genetically unstable transformed cells. Stem cells are therapeutic targets for prostate cancer, but since disease progression occurs over decades, the imperative is to identify and target the cancer repopulating cell that maintains malignant clones. In order to achieve this goal, we will review the current knowledge of three specific types of cells, their origins, and their differentiation potential. The first is the normal stem cell, the second is the cancer cell of origin and the third is the cancer repopulating cell. Specifically, we review three proposed models of stem cell differentiation in normal tissues, including linear, bi-directional and independent lineages. We consider evidence of the cancer cell of origin arising from both basal and luminal cells. Finally, we discuss the limited data available on the identity and characterization of cancer-repopulating cells in localized and castrate-resistant prostate cancer, which is where we believe the focus of future research efforts should be directed. Ultimately, understanding the intrinsic or extrinsic influences that dictate the behavior of these unique cells will be instrumental in facilitating the development of new therapeutic targets for prostate cancer.
Original languageEnglish
Pages (from-to)R273 - R285
Number of pages13
JournalEndocrine-Related Cancer
Volume17
Issue number4
DOIs
Publication statusPublished - 2010

Cite this

@article{69478ba318764e05849140260d86c378,
title = "Stem cells in prostate cancer: Treating the root of the problem",
abstract = "Prostate cancer is a hormone-dependent, epithelial-derived tumor, resulting from uncontrolled growth of genetically unstable transformed cells. Stem cells are therapeutic targets for prostate cancer, but since disease progression occurs over decades, the imperative is to identify and target the cancer repopulating cell that maintains malignant clones. In order to achieve this goal, we will review the current knowledge of three specific types of cells, their origins, and their differentiation potential. The first is the normal stem cell, the second is the cancer cell of origin and the third is the cancer repopulating cell. Specifically, we review three proposed models of stem cell differentiation in normal tissues, including linear, bi-directional and independent lineages. We consider evidence of the cancer cell of origin arising from both basal and luminal cells. Finally, we discuss the limited data available on the identity and characterization of cancer-repopulating cells in localized and castrate-resistant prostate cancer, which is where we believe the focus of future research efforts should be directed. Ultimately, understanding the intrinsic or extrinsic influences that dictate the behavior of these unique cells will be instrumental in facilitating the development of new therapeutic targets for prostate cancer.",
author = "Taylor, {Renea Anne} and Roxanne Toivanen and Risbridger, {Gail Petuna}",
year = "2010",
doi = "10.1677/ERC-10-0145",
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pages = "R273 -- R285",
journal = "Endocrine-Related Cancer",
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Stem cells in prostate cancer: Treating the root of the problem. / Taylor, Renea Anne; Toivanen, Roxanne; Risbridger, Gail Petuna.

In: Endocrine-Related Cancer, Vol. 17, No. 4, 2010, p. R273 - R285.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Stem cells in prostate cancer: Treating the root of the problem

AU - Taylor, Renea Anne

AU - Toivanen, Roxanne

AU - Risbridger, Gail Petuna

PY - 2010

Y1 - 2010

N2 - Prostate cancer is a hormone-dependent, epithelial-derived tumor, resulting from uncontrolled growth of genetically unstable transformed cells. Stem cells are therapeutic targets for prostate cancer, but since disease progression occurs over decades, the imperative is to identify and target the cancer repopulating cell that maintains malignant clones. In order to achieve this goal, we will review the current knowledge of three specific types of cells, their origins, and their differentiation potential. The first is the normal stem cell, the second is the cancer cell of origin and the third is the cancer repopulating cell. Specifically, we review three proposed models of stem cell differentiation in normal tissues, including linear, bi-directional and independent lineages. We consider evidence of the cancer cell of origin arising from both basal and luminal cells. Finally, we discuss the limited data available on the identity and characterization of cancer-repopulating cells in localized and castrate-resistant prostate cancer, which is where we believe the focus of future research efforts should be directed. Ultimately, understanding the intrinsic or extrinsic influences that dictate the behavior of these unique cells will be instrumental in facilitating the development of new therapeutic targets for prostate cancer.

AB - Prostate cancer is a hormone-dependent, epithelial-derived tumor, resulting from uncontrolled growth of genetically unstable transformed cells. Stem cells are therapeutic targets for prostate cancer, but since disease progression occurs over decades, the imperative is to identify and target the cancer repopulating cell that maintains malignant clones. In order to achieve this goal, we will review the current knowledge of three specific types of cells, their origins, and their differentiation potential. The first is the normal stem cell, the second is the cancer cell of origin and the third is the cancer repopulating cell. Specifically, we review three proposed models of stem cell differentiation in normal tissues, including linear, bi-directional and independent lineages. We consider evidence of the cancer cell of origin arising from both basal and luminal cells. Finally, we discuss the limited data available on the identity and characterization of cancer-repopulating cells in localized and castrate-resistant prostate cancer, which is where we believe the focus of future research efforts should be directed. Ultimately, understanding the intrinsic or extrinsic influences that dictate the behavior of these unique cells will be instrumental in facilitating the development of new therapeutic targets for prostate cancer.

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