Stem cells behind the barrier

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Epidermal stem cells sustain the adult skin for a lifetime through self-renewal and the production of committed progenitors. These stem cells generate progeny that will undergo terminal differentiation leading to the development of a protective epidermal barrier. Whereas the molecular mechanisms that govern epidermal barrier repair and renewal have been extensively studied, pathways controlling stem cell differentiation remain poorly understood. Asymmetric cell divisions, small non-coding RNAs (microRNAs), chromatin remodeling complexes, and multiple differentiation factors tightly control the balance of stem and progenitor cell proliferation and differentiation, and disruption of this balance leads to skin diseases. In this review, we summarize and discuss current advances in our understanding of the mechanisms regulating epidermal stem and progenitor cell differentiation, and explore new relationships for maintenance of skin barrier function. ? 2013 by the authors; licensee MDPI, Basel, Switzerland.
Original languageEnglish
Pages (from-to)13670 - 13686
Number of pages17
JournalInternational Journal of Molecular Sciences
Volume14
Issue number7
DOIs
Publication statusPublished - 2013

Cite this

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title = "Stem cells behind the barrier",
abstract = "Epidermal stem cells sustain the adult skin for a lifetime through self-renewal and the production of committed progenitors. These stem cells generate progeny that will undergo terminal differentiation leading to the development of a protective epidermal barrier. Whereas the molecular mechanisms that govern epidermal barrier repair and renewal have been extensively studied, pathways controlling stem cell differentiation remain poorly understood. Asymmetric cell divisions, small non-coding RNAs (microRNAs), chromatin remodeling complexes, and multiple differentiation factors tightly control the balance of stem and progenitor cell proliferation and differentiation, and disruption of this balance leads to skin diseases. In this review, we summarize and discuss current advances in our understanding of the mechanisms regulating epidermal stem and progenitor cell differentiation, and explore new relationships for maintenance of skin barrier function. ? 2013 by the authors; licensee MDPI, Basel, Switzerland.",
author = "Michael Cangkrama and Ting, {Stephen Bek Ngie} and Charbel Darido",
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Stem cells behind the barrier. / Cangkrama, Michael; Ting, Stephen Bek Ngie; Darido, Charbel.

In: International Journal of Molecular Sciences, Vol. 14, No. 7, 2013, p. 13670 - 13686.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Stem cells behind the barrier

AU - Cangkrama, Michael

AU - Ting, Stephen Bek Ngie

AU - Darido, Charbel

PY - 2013

Y1 - 2013

N2 - Epidermal stem cells sustain the adult skin for a lifetime through self-renewal and the production of committed progenitors. These stem cells generate progeny that will undergo terminal differentiation leading to the development of a protective epidermal barrier. Whereas the molecular mechanisms that govern epidermal barrier repair and renewal have been extensively studied, pathways controlling stem cell differentiation remain poorly understood. Asymmetric cell divisions, small non-coding RNAs (microRNAs), chromatin remodeling complexes, and multiple differentiation factors tightly control the balance of stem and progenitor cell proliferation and differentiation, and disruption of this balance leads to skin diseases. In this review, we summarize and discuss current advances in our understanding of the mechanisms regulating epidermal stem and progenitor cell differentiation, and explore new relationships for maintenance of skin barrier function. ? 2013 by the authors; licensee MDPI, Basel, Switzerland.

AB - Epidermal stem cells sustain the adult skin for a lifetime through self-renewal and the production of committed progenitors. These stem cells generate progeny that will undergo terminal differentiation leading to the development of a protective epidermal barrier. Whereas the molecular mechanisms that govern epidermal barrier repair and renewal have been extensively studied, pathways controlling stem cell differentiation remain poorly understood. Asymmetric cell divisions, small non-coding RNAs (microRNAs), chromatin remodeling complexes, and multiple differentiation factors tightly control the balance of stem and progenitor cell proliferation and differentiation, and disruption of this balance leads to skin diseases. In this review, we summarize and discuss current advances in our understanding of the mechanisms regulating epidermal stem and progenitor cell differentiation, and explore new relationships for maintenance of skin barrier function. ? 2013 by the authors; licensee MDPI, Basel, Switzerland.

UR - http://www.mdpi.com/1422-0067/14/7/13670

U2 - 10.3390/ijms140713670

DO - 10.3390/ijms140713670

M3 - Article

VL - 14

SP - 13670

EP - 13686

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 7

ER -