TY - JOUR
T1 - Stem cell decision making and critical-like exploratory networks
AU - Halley, Julianne Debbie
AU - Burden, Frank Robert
AU - Winkler, David Alan
PY - 2009
Y1 - 2009
N2 - A sound theoretical or conceptual model of gene regulatory processes that control stem cell fate is still lacking, compromising our ability to manipulate stem cells for therapeutic benefit. The complexity of the regulatory and signaling pathways limits development of useful, predictive models that employ solely reductionist methods using molecular components. However, there is clear evidence from other complex systems that coarse-grained or mesoscale models can yield useful insights and provide workable models for the prediction of some emergent properties such as cell phenotype.
AB - A sound theoretical or conceptual model of gene regulatory processes that control stem cell fate is still lacking, compromising our ability to manipulate stem cells for therapeutic benefit. The complexity of the regulatory and signaling pathways limits development of useful, predictive models that employ solely reductionist methods using molecular components. However, there is clear evidence from other complex systems that coarse-grained or mesoscale models can yield useful insights and provide workable models for the prediction of some emergent properties such as cell phenotype.
UR - http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B8G43-4VVR22W-1-5&_cdi=41811&_user=542840&_pii=S1873506109000270&_orig=search&_coverDate=05%2F
U2 - 10.1016/j.scr.2009.03.001
DO - 10.1016/j.scr.2009.03.001
M3 - Article
VL - 2
SP - 165
EP - 177
JO - Stem Cell Research
JF - Stem Cell Research
SN - 1873-5061
IS - 3
ER -