Status of clomiphene citrate and metformin for infertility in PCOS

Marie Louise Misso, Helena Jane Teede, Roger Hart, Jennifer Lee Ann Wong, Luk Rombauts, Angela M Melder, Robert J Norman, Michael F Costello

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)


Though widely used, there is uncertainty about the effectiveness and adverse effects of metformin and clomiphene citrate (CC) for infertility in polycystic ovary syndrome (PCOS). A systematic review (SR) of the best available evidence suggests that both CC and metformin are better than placebo for increasing ovulation and pregnancy rates, but CC is more effective than metformin for ovulation, pregnancy and live-birth rates, in PCOS patients with body mass index (BMI) >30. A combination of CC and metformin is superior to either metformin alone or CC alone, depending on the BMI and CC sensitivity of the patient. This SR provides key messages to guide clinicians and consumers on the use of these interventions in different subgroups of women with PCOS.
Original languageEnglish
Pages (from-to)533 - 543
Number of pages11
JournalTrends in Endocrinology & Metabolism
Issue number10
Publication statusPublished - 2012

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