Statistical analysis plan (SAP) for the Very Early Rehabilitation in Speech (VERSE) after stroke trial: an international 3-arm clinical trial to determine the effectiveness of early, intensive, prescribed, direct aphasia therapy

Erin Godecke, Tapan Rai, Dominique A. Cadilhac, Elizabeth Armstrong, Sandy Middleton, Natalie Ciccone, Anne Whitworth, Miranda L. Rose, Audrey Holland, Fiona Ellery, Graeme J. Hankey, Julie Bernhardt, for the VERSE Collaboration

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1 Citation (Scopus)

Abstract

Background: Limited evidence exists to support very early intensive aphasia rehabilitation after stroke. VERSE is a PROBE trial designed to determine whether two types of intensive aphasia therapy, beginning within 14 days of acute stroke, provide greater therapeutic and cost-effectiveness than usual care. Objective: To publish the detailed statistical analysis plan for the VERSE trial prior to unblinding. This statistical analysis plan was based on the published and registered VERSE trial protocol and was developed by the blinded steering committee and management team, led by the trial statistician. This plan was developed using outcome measures and trial data collection forms. Results: The VERSE statistical analysis plan is consistent with reporting standards for clinical trials and provides for clear and open reporting. Conclusions: Publication of a statistical analysis plan serves to reduce potential trial reporting bias and outlines transparent pre-specified analyses. Australian New Zealand Clinical Trials Registry (ANZCTR) Registration number: ACTRN12613000776707; Universal Trial Number (UTN) is U1111-1145-4130.

Original languageEnglish
Pages (from-to)863-880
Number of pages18
JournalInternational Journal of Stroke
Volume13
Issue number8
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • Aphasia
  • Randomised controlled trial
  • Statistical analysis plan
  • Stroke Rehabilitation

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