TY - JOUR
T1 - Statins in heart failure: do we need another trial?
AU - Osei Bonsu, Kwadwo
AU - Kadirvelu, Amudha
AU - Reidpath, Daniel
PY - 2013
Y1 - 2013
N2 - Statins lower serum cholesterol and are employed for primary and secondary prevention of cardiovascular events. Clinical evidence from observational studies, retrospective data, and post hoc analyses of data from large statin trials in various cardiovascular conditions, as well as small scale randomized trials, suggest survival and other outcome benefits for heart failure. Two recent large randomized controlled trials, however, appear to suggest statins do not have beneficial effects in heart failure. In addition to lowering cholesterol, statins are believed to have many pleotropic effects which could possibly influence the pathophysiology of heart failure. Following the two large trials, evidence from recent studies appears to support the use of statins in heart failure. This review discusses the role of statins in the pathophysiology of heart failure, current evidence for statin use in heart failure, and suggests directions for future research
AB - Statins lower serum cholesterol and are employed for primary and secondary prevention of cardiovascular events. Clinical evidence from observational studies, retrospective data, and post hoc analyses of data from large statin trials in various cardiovascular conditions, as well as small scale randomized trials, suggest survival and other outcome benefits for heart failure. Two recent large randomized controlled trials, however, appear to suggest statins do not have beneficial effects in heart failure. In addition to lowering cholesterol, statins are believed to have many pleotropic effects which could possibly influence the pathophysiology of heart failure. Following the two large trials, evidence from recent studies appears to support the use of statins in heart failure. This review discusses the role of statins in the pathophysiology of heart failure, current evidence for statin use in heart failure, and suggests directions for future research
UR - http://www.dovepress.com/statins-in-heart-failure-do-we-need-another-trial-peer-reviewed-article-VHRM
U2 - 10.2147/VHRM.S44499
DO - 10.2147/VHRM.S44499
M3 - Article
SN - 1176-6344
VL - 9
SP - 303
EP - 319
JO - Vascular Health and Risk Management
JF - Vascular Health and Risk Management
IS - 1
ER -