TY - JOUR
T1 - Statin therapy and outcome after ischemic stroke: systematic review and meta-analysis of observational studies and randomized trials
AU - Chroinin, Danielle Ni
AU - Asplund, Kjell
AU - Asberg, Signild
AU - Callaly, Elizabeth
AU - Cuadrado-Godia, Elisa
AU - Diez-Tejedor, Exuperio
AU - Di Napoli, Mario
AU - Engelter, Stefan T
AU - Furie, Karen L
AU - Giannopoulos, Sotirios
AU - Gotto, Antonio M
AU - Hannon, Niamh
AU - Jonsson, Fredrik
AU - Kapral, Moira K
AU - Marti-Fabregas, Joan
AU - Martinez-Sanchez, Patricia
AU - Milionis, Haralampos J
AU - Montaner, Joan
AU - Muscari, Antonio
AU - Pikija, Slaven
AU - Probstfield, Jeffrey
AU - Rost, Natalia S
AU - Thrift, Amanda Gay
AU - Vemmos, Konstantinos
AU - Kelly, Peter J
PY - 2013
Y1 - 2013
N2 - Although experimental data suggest that statin therapy may improve neurological outcome after acute cerebral ischemia, the results from clinical studies are conflicting. We performed a systematic review and meta-analysis investigating the relationship between statin therapy and outcome after ischemic stroke. METHODS - : The primary analysis investigated statin therapy at stroke onset (prestroke statin use) and good functional outcome (modified Rankin score 0 to 2) and death. Secondary analyses included the following: (1) acute poststroke statin therapy (=72 hours after stroke), and (2) thrombolysis-treated patients. RESULTS - : The primary analysis included 113 148 subjects (27 studies). Among observational studies, statin treatment at stroke onset was associated with good functional outcome at 90 days (pooled odds ratio [OR], 1.41; 95 confidence interval [CI], 1.29-1.56; P
AB - Although experimental data suggest that statin therapy may improve neurological outcome after acute cerebral ischemia, the results from clinical studies are conflicting. We performed a systematic review and meta-analysis investigating the relationship between statin therapy and outcome after ischemic stroke. METHODS - : The primary analysis investigated statin therapy at stroke onset (prestroke statin use) and good functional outcome (modified Rankin score 0 to 2) and death. Secondary analyses included the following: (1) acute poststroke statin therapy (=72 hours after stroke), and (2) thrombolysis-treated patients. RESULTS - : The primary analysis included 113 148 subjects (27 studies). Among observational studies, statin treatment at stroke onset was associated with good functional outcome at 90 days (pooled odds ratio [OR], 1.41; 95 confidence interval [CI], 1.29-1.56; P
UR - http://stroke.ahajournals.org/content/44/2/448.full.pdf+html
U2 - 10.1161/STROKEAHA.112.668277
DO - 10.1161/STROKEAHA.112.668277
M3 - Article
SN - 0039-2499
VL - 44
SP - 448
EP - 456
JO - Stroke
JF - Stroke
IS - 2
ER -