Statin therapy and outcome after ischemic stroke: systematic review and meta-analysis of observational studies and randomized trials

Danielle Ni Chroinin, Kjell Asplund, Signild Asberg, Elizabeth Callaly, Elisa Cuadrado-Godia, Exuperio Diez-Tejedor, Mario Di Napoli, Stefan T Engelter, Karen L Furie, Sotirios Giannopoulos, Antonio M Gotto, Niamh Hannon, Fredrik Jonsson, Moira K Kapral, Joan Marti-Fabregas, Patricia Martinez-Sanchez, Haralampos J Milionis, Joan Montaner, Antonio Muscari, Slaven PikijaJeffrey Probstfield, Natalia S Rost, Amanda Gay Thrift, Konstantinos Vemmos, Peter J Kelly

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203 Citations (Scopus)


Although experimental data suggest that statin therapy may improve neurological outcome after acute cerebral ischemia, the results from clinical studies are conflicting. We performed a systematic review and meta-analysis investigating the relationship between statin therapy and outcome after ischemic stroke. METHODS - : The primary analysis investigated statin therapy at stroke onset (prestroke statin use) and good functional outcome (modified Rankin score 0 to 2) and death. Secondary analyses included the following: (1) acute poststroke statin therapy (=72 hours after stroke), and (2) thrombolysis-treated patients. RESULTS - : The primary analysis included 113 148 subjects (27 studies). Among observational studies, statin treatment at stroke onset was associated with good functional outcome at 90 days (pooled odds ratio [OR], 1.41; 95 confidence interval [CI], 1.29-1.56; P
Original languageEnglish
Pages (from-to)448 - 456
Number of pages9
Issue number2
Publication statusPublished - 2013

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