State-dependent modulation of slow wave motifs towards awakening

Daisuke Shimaoka, Chenchen Song, Thomas Knöpfel

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Slow cortical waves that propagate across the cerebral cortex forming large-scale spatiotemporal propagation patterns are a hallmark of non-REM sleep and anesthesia, but also occur during resting wakefulness. To investigate how the spatial temporal properties of slow waves change with the depth of anesthetic, we optically imaged population voltage transients generated by mouse layer 2/3 pyramidal neurons across one or two cortical hemispheres dorsally with a genetically encoded voltage indicator (GEVI). From deep barbiturate anesthesia to light barbiturate sedation, depolarizing wave events recruiting at least 50% of the imaged cortical area consistently appeared as a conserved repertoire of distinct wave motifs. Toward awakening, the incidence of individual motifs changed systematically (the motif propagating from visual to motor areas increased while that from somatosensory to visual areas decreased) and both local and global cortical dynamics accelerated. These findings highlight that functional endogenous interactions between distant cortical areas are not only constrained by anatomical connectivity, but can also be modulated by the brain state.

Original languageEnglish
Article number108
Number of pages11
JournalFrontiers in Cellular Neuroscience
Volume11
DOIs
Publication statusPublished - 24 Apr 2017
Externally publishedYes

Keywords

  • Cortical circuit dynamics
  • Genetically encoded voltage indicators
  • Global wave events
  • Optical voltage imaging
  • Slow cortical waves
  • Spatiotemporal motifs

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