Star-shaped block copolymers by copper-catalyzed azide-alkyne cycloaddition for potential drug delivery applications

Christian Von Der Ehe, Kristian Kempe, Marius Bauer, Anja Baumgaertel, Martin D. Hager, Dagmar Fischer, Ulrich S. Schubert

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Star-shaped poly(μ-caprolactone) is synthesized by ring-opening polymerization and subsequently functionalized with alkyne groups. These are utilized for the attachment of linear poly(ethylene glycol) monomethyl ether azide (mPEG-N 3) and poly(2-ethyl-2-oxazoline) azide (PEtOx-N 3) by copper-catalyzed azide-alkyne cycloaddition (CuAAC). The resulting amphiphilic star-shaped block copolymers are characterized by SEC, MALDI-TOF mass spectrometry, NMR spectroscopy, and DLS. In order to elucidate the potential of both systems as drug carriers their loading capacity is studied with a model system, the hydrophobic dye fat brown RR. Furthermore, erythrocyte aggregation tests provide first indications that the two different star-shaped block copolymers are compatible for potential applications in a biological context.

Original languageEnglish
Pages (from-to)2146-2156
Number of pages11
JournalMacromolecular Chemistry and Physics
Volume213
Issue number20
DOIs
Publication statusPublished - 26 Oct 2012
Externally publishedYes

Keywords

  • CuAAC
  • micelles
  • poly(μ-caprolactone)s
  • poly(2-ethyl-2-oxazoline)s
  • star polymers

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