Stage-specific inhibin secretion by rat seminiferous tubules

G. F. Gonzales, G. P. Risbridger, Y. H. Hodgson, P. Pöllönen, D. M. De Kretser

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The endogenous inhibin content was measured by radioimmunoassay in segments of seminiferous tubules at specific stages of the spermatogenic cycle isolated by transillumination-assisted dissection as described by Parvinen (1982). In addition, the immunoactive inhibin production in response to FSH stimulation was investigated. The inhibin content was greatest in tubules at stages II-VI of the cycle and was lowest at stages VII-VIII. Over 48 h of culture, the secretion of inhibin into the medium was greatest at stages XIII-VI and lowest at stages VII-VIII. The inhibin response to FSH stimulation was greatest at stages IX-XIII and least at stages VII-VIII. The results demonstrate that the secretion of inhibin by adult tubules in vitro varies according to the stage of the seminiferous cycle.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalReproduction, Fertility and Development
Issue number3
Publication statusPublished - 1989


  • FSH

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