Stable aqueous dispersions of glycopeptide-grafted selectably functionalized magnetic nanoparticles

Tushar Borase; Tsedev Ninjbadgar; Antonios Kapetanakis; Sandra Roche; Robert O'Connor; Christian Kerskens; Andreas Heise; Dermot F. Brougham

doi:10.1002/anie.201208099

Stable aqueous dispersions of glycopeptide-grafted selectably functionalized magnetic nanoparticles

Tushar Borase, Tsedev Ninjbadgar, Antonios Kapetanakis, Sandra Roche, Robert O'Connor, Christian Kerskens, Andreas Heise, Dermot F. Brougham

Research output: Contribution to journal › Article › Research › peer-review

85 Citations (Scopus)

Abstract

Sweet nanomagnets: Suspensions of glycopeptide grafted magnetic nanoparticles can be produced by N-carboxyanhydride ring-opening polymerization with subsequent click glycosylation. The resulting materials have a high sugar density, optimal dispersion and T₁-weighted MRI properties, and bio-recognition ability. The approach can be used to attach any type or combination of functional groups, the density of which is not limited by particle surface area.

Original language	English
Pages (from-to)	3164-3167
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	11
DOIs	https://doi.org/10.1002/anie.201208099
Publication status	Published - 11 Mar 2013
Externally published	Yes

Keywords

click chemistry
glycopeptides
ligands
magnetic nanoparticles
ring-opening polymerization

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10.1002/anie.201208099

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abstract = "Sweet nanomagnets: Suspensions of glycopeptide grafted magnetic nanoparticles can be produced by N-carboxyanhydride ring-opening polymerization with subsequent click glycosylation. The resulting materials have a high sugar density, optimal dispersion and T1-weighted MRI properties, and bio-recognition ability. The approach can be used to attach any type or combination of functional groups, the density of which is not limited by particle surface area.",

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AU - O'Connor, Robert

AU - Kerskens, Christian

AU - Heise, Andreas

AU - Brougham, Dermot F.

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KW - click chemistry

KW - glycopeptides

KW - ligands

KW - magnetic nanoparticles

KW - ring-opening polymerization

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Stable aqueous dispersions of glycopeptide-grafted selectably functionalized magnetic nanoparticles

Abstract

Keywords

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