Stability of extemporaneously prepared 0.5-percent caspofungin eye drops: a potential cost-savings exercise

Chin Fen Neoh, Jovan Jacob, Lok Leung, Jian Li, Angela Stathopoulos, Kay Stewart, David Chee Ming Kong

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5 ) eye drops were aseptically prepared, and the concentrations were measured using a validated high-performance liquid chromatography (HPLC) analysis. The preparations remained stable for 28 days under refrigerated condition but not at 25.0A?C. Our study supports the cost-saving use of caspofungin eye drops in the clinical setting.
Original languageEnglish
Pages (from-to)3435 - 3437
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number6
DOIs
Publication statusPublished - 2012

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