TY - JOUR
T1 - Stability of extemporaneously prepared 0.5-percent caspofungin eye drops: a potential cost-savings exercise
AU - Neoh, Chin Fen
AU - Jacob, Jovan
AU - Leung, Lok
AU - Li, Jian
AU - Stathopoulos, Angela
AU - Stewart, Kay
AU - Kong, David Chee Ming
PY - 2012
Y1 - 2012
N2 - While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available
and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5 ) eye drops were aseptically
prepared, and the concentrations were measured using a validated high-performance liquid chromatography (HPLC) analysis.
The preparations remained stable for 28 days under refrigerated condition but not at 25.0A?C. Our study supports the cost-saving
use of caspofungin eye drops in the clinical setting.
AB - While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available
and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5 ) eye drops were aseptically
prepared, and the concentrations were measured using a validated high-performance liquid chromatography (HPLC) analysis.
The preparations remained stable for 28 days under refrigerated condition but not at 25.0A?C. Our study supports the cost-saving
use of caspofungin eye drops in the clinical setting.
UR - http://aac.asm.org/content/56/6/3435
U2 - 10.1128/AAC.00060-12
DO - 10.1128/AAC.00060-12
M3 - Article
SN - 1098-6596
VL - 56
SP - 3435
EP - 3437
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 6
ER -