Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures

Monalisa Swain, R. Thirupathi, B. Krishnarjuna, Erin M. Eaton, Megan M. Kibbey, Steven A. Rosenzweig, Hanudatta S. Atreya

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)


In this communication, we report the spontaneous and reversible in vitro self-assembly of a polypeptide fragment derived from the C-terminal domain of Insulin-like Growth Factor Binding Protein (IGFBP-2) into soluble nanotubular structures several micrometres long via a mechanism involving inter-molecular disulfide bonds and exhibiting enhanced fluorescence.

Original languageEnglish
Article number1
Pages (from-to)216-218
Number of pages3
JournalChemical Communications
Issue number2
Publication statusPublished - 5 Feb 2010
Externally publishedYes

Cite this