Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes

Yuxiang Dong, Jacques Chollet, Hugues Matile, Susan A Charman, Francis Chi Keung Chiu, William Neil Charman, Bernard Scorneaux, Heinrich Urwyler, Josefina Santo Tomas, Christian Scheurer, Christopher Snyder, Arnulf Dorn, Xiaofang Wang, Jean M Karle, Yuanqing Tang, Sergio Wittlin, Reto Brun, Jonathan L Vennerstrom

Research output: Contribution to journalArticleResearchpeer-review

91 Citations (Scopus)
Original languageEnglish
Pages (from-to)4953 - 4961
Number of pages9
JournalJournal of Medicinal Chemistry
Volume48
Issue number15
DOIs
Publication statusPublished - 2005

Cite this

Dong, Yuxiang ; Chollet, Jacques ; Matile, Hugues ; Charman, Susan A ; Chiu, Francis Chi Keung ; Charman, William Neil ; Scorneaux, Bernard ; Urwyler, Heinrich ; Santo Tomas, Josefina ; Scheurer, Christian ; Snyder, Christopher ; Dorn, Arnulf ; Wang, Xiaofang ; Karle, Jean M ; Tang, Yuanqing ; Wittlin, Sergio ; Brun, Reto ; Vennerstrom, Jonathan L. / Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes. In: Journal of Medicinal Chemistry. 2005 ; Vol. 48, No. 15. pp. 4953 - 4961.
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title = "Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes",
author = "Yuxiang Dong and Jacques Chollet and Hugues Matile and Charman, {Susan A} and Chiu, {Francis Chi Keung} and Charman, {William Neil} and Bernard Scorneaux and Heinrich Urwyler and {Santo Tomas}, Josefina and Christian Scheurer and Christopher Snyder and Arnulf Dorn and Xiaofang Wang and Karle, {Jean M} and Yuanqing Tang and Sergio Wittlin and Reto Brun and Vennerstrom, {Jonathan L}",
year = "2005",
doi = "10.1021/jm049040u",
language = "English",
volume = "48",
pages = "4953 -- 4961",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "AMER CHEMICAL SOC",
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Dong, Y, Chollet, J, Matile, H, Charman, SA, Chiu, FCK, Charman, WN, Scorneaux, B, Urwyler, H, Santo Tomas, J, Scheurer, C, Snyder, C, Dorn, A, Wang, X, Karle, JM, Tang, Y, Wittlin, S, Brun, R & Vennerstrom, JL 2005, 'Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes', Journal of Medicinal Chemistry, vol. 48, no. 15, pp. 4953 - 4961. https://doi.org/10.1021/jm049040u

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes. / Dong, Yuxiang; Chollet, Jacques; Matile, Hugues; Charman, Susan A; Chiu, Francis Chi Keung; Charman, William Neil; Scorneaux, Bernard; Urwyler, Heinrich; Santo Tomas, Josefina; Scheurer, Christian; Snyder, Christopher; Dorn, Arnulf; Wang, Xiaofang; Karle, Jean M; Tang, Yuanqing; Wittlin, Sergio; Brun, Reto; Vennerstrom, Jonathan L.

In: Journal of Medicinal Chemistry, Vol. 48, No. 15, 2005, p. 4953 - 4961.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes

AU - Dong, Yuxiang

AU - Chollet, Jacques

AU - Matile, Hugues

AU - Charman, Susan A

AU - Chiu, Francis Chi Keung

AU - Charman, William Neil

AU - Scorneaux, Bernard

AU - Urwyler, Heinrich

AU - Santo Tomas, Josefina

AU - Scheurer, Christian

AU - Snyder, Christopher

AU - Dorn, Arnulf

AU - Wang, Xiaofang

AU - Karle, Jean M

AU - Tang, Yuanqing

AU - Wittlin, Sergio

AU - Brun, Reto

AU - Vennerstrom, Jonathan L

PY - 2005

Y1 - 2005

U2 - 10.1021/jm049040u

DO - 10.1021/jm049040u

M3 - Article

VL - 48

SP - 4953

EP - 4961

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 15

ER -