Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes

Yuxiang Dong; Jacques Chollet; Hugues Matile; Susan A Charman; Francis Chi Keung Chiu; William Neil Charman; Bernard Scorneaux; Heinrich Urwyler; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Arnulf Dorn; Xiaofang Wang; Jean M Karle; Yuanqing Tang; Sergio Wittlin; Reto Brun; Jonathan L Vennerstrom

doi:10.1021/jm049040u

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes

Yuxiang Dong, Jacques Chollet, Hugues Matile, Susan A Charman, Francis Chi Keung Chiu, William Neil Charman, Bernard Scorneaux, Heinrich Urwyler, Josefina Santo Tomas, Christian Scheurer, Christopher Snyder, Arnulf Dorn, Xiaofang Wang, Jean M Karle, Yuanqing Tang, Sergio Wittlin, Reto Brun, Jonathan L Vennerstrom

Research output: Contribution to journal › Article › Research › peer-review

117 Citations (Scopus)

Original language	English
Pages (from-to)	4953 - 4961
Number of pages	9
Journal	Journal of Medicinal Chemistry
Volume	48
Issue number	15
DOIs	https://doi.org/10.1021/jm049040u
Publication status	Published - 2005

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10.1021/jm049040u

Cite this

Dong, Y., Chollet, J., Matile, H., Charman, S. A., Chiu, F. C. K., Charman, W. N., Scorneaux, B., Urwyler, H., Santo Tomas, J., Scheurer, C., Snyder, C., Dorn, A., Wang, X., Karle, J. M., Tang, Y., Wittlin, S., Brun, R., & Vennerstrom, J. L. (2005). Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes. Journal of Medicinal Chemistry, 48(15), 4953 - 4961. https://doi.org/10.1021/jm049040u

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title = "Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes",

author = "Yuxiang Dong and Jacques Chollet and Hugues Matile and Charman, {Susan A} and Chiu, {Francis Chi Keung} and Charman, {William Neil} and Bernard Scorneaux and Heinrich Urwyler and {Santo Tomas}, Josefina and Christian Scheurer and Christopher Snyder and Arnulf Dorn and Xiaofang Wang and Karle, {Jean M} and Yuanqing Tang and Sergio Wittlin and Reto Brun and Vennerstrom, {Jonathan L}",

year = "2005",

doi = "10.1021/jm049040u",

language = "English",

volume = "48",

pages = "4953 -- 4961",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

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Dong, Y, Chollet, J, Matile, H, Charman, SA, Chiu, FCK, Charman, WN, Scorneaux, B, Urwyler, H, Santo Tomas, J, Scheurer, C, Snyder, C, Dorn, A, Wang, X, Karle, JM, Tang, Y, Wittlin, S, Brun, R & Vennerstrom, JL 2005, 'Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes', Journal of Medicinal Chemistry, vol. 48, no. 15, pp. 4953 - 4961. https://doi.org/10.1021/jm049040u

TY - JOUR

T1 - Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes

AU - Dong, Yuxiang

AU - Chollet, Jacques

AU - Matile, Hugues

AU - Charman, Susan A

AU - Chiu, Francis Chi Keung

AU - Charman, William Neil

AU - Scorneaux, Bernard

AU - Urwyler, Heinrich

AU - Santo Tomas, Josefina

AU - Scheurer, Christian

AU - Snyder, Christopher

AU - Dorn, Arnulf

AU - Wang, Xiaofang

AU - Karle, Jean M

AU - Tang, Yuanqing

AU - Wittlin, Sergio

AU - Brun, Reto

AU - Vennerstrom, Jonathan L

PY - 2005

Y1 - 2005

U2 - 10.1021/jm049040u

DO - 10.1021/jm049040u

M3 - Article

SN - 0022-2623

VL - 48

SP - 4953

EP - 4961

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 15

ER -