|Title of host publication||Encyclopedia of Reproduction|
|Editors||Michael K. Skinner|
|Number of pages||6|
|Publication status||Published - 2018|
This chapter describes spermiation, the final step of spermatogenesis (sperm production). Spermiation involves the final remodeling and release of sperm from the Sertoli cells of the seminiferous epithelium, prior to their passage to the epididymis. It is a long, multistep process involving different adhesion and signaling molecules and cytoskeletal structures. During spermiation, spermatids are remodeled to remove their extensive cytoplasm and reveal a streamlined nucleus and flagella that is characteristic of motile spermatozoa. Spermiation is highly vulnerable to disruption and an important determinant of sperm number and morphology in the ejaculate and, therefore, of fertility.