Spermatogenesis

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Spermatogenesis takes place within the seminiferous tubules and involves the replication of stem cells to enable continuous sperm production over the male life span. The process involves mitotic replication of spermatogonia and the subsequent reduction of chromosome number in primary and secondary spermatocytes to the haploid state. The haploid spermatids undergo a complex differentiation process, termed spermiogenesis, resulting in compaction of the nucleus to form the sperm head, the development of the acrosome and sperm tail, a reorganization of the cell organelles, and a shedding of excess cytoplasm. The entire spermatogenic process is highly regulated, and the progression from spermatogonia to sperm takes a fixed duration that differs among species. The only germ cells in contact with the extratubular environment are the spermatogonia. This is because the rest of the germ cell types are lodged within the intratubular immunologically privileged environment controlled by the Sertoli cells that support the developing germ cells structurally and form the blood-testis barrier. The extratubular compartment contains blood vessels that are surrounded by Leydig cells that produce and secrete testosterone, which, together with the gondadotropic hormones FSH and LH, are critical for the production of sperm.
Original languageEnglish
Title of host publicationEndocrinology
Subtitle of host publicationAdult & Pediatric
EditorsJ Larry Jameson, Leslie J De Groot, David M de Kretser, Linda C Giudice, Ashley B Grossman, Shlomo Melmed, John T Potts Jr, Gordon C Weir
Place of PublicationPhiladelphia PA USA
PublisherElsevier
Pages2325 - 2353
Number of pages29
Volume1 and 2
Edition7th
ISBN (Print)9780323189071
Publication statusPublished - 2016

Cite this

de Kretser, D. M., Loveland, K. A. L., & O'Bryan, M. K. (2016). Spermatogenesis. In J. L. Jameson, L. J. De Groot, D. M. de Kretser, L. C. Giudice, A. B. Grossman, S. Melmed, J. T. Potts Jr, ... G. C. Weir (Eds.), Endocrinology: Adult & Pediatric (7th ed., Vol. 1 and 2, pp. 2325 - 2353). Philadelphia PA USA: Elsevier.
de Kretser, David M ; Loveland, Katherine A L ; O'Bryan, Moira K. / Spermatogenesis. Endocrinology: Adult & Pediatric. editor / J Larry Jameson ; Leslie J De Groot ; David M de Kretser ; Linda C Giudice ; Ashley B Grossman ; Shlomo Melmed ; John T Potts Jr ; Gordon C Weir. Vol. 1 and 2 7th. ed. Philadelphia PA USA : Elsevier, 2016. pp. 2325 - 2353
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de Kretser, DM, Loveland, KAL & O'Bryan, MK 2016, Spermatogenesis. in JL Jameson, LJ De Groot, DM de Kretser, LC Giudice, AB Grossman, S Melmed, JT Potts Jr & GC Weir (eds), Endocrinology: Adult & Pediatric. 7th edn, vol. 1 and 2, Elsevier, Philadelphia PA USA, pp. 2325 - 2353.

Spermatogenesis. / de Kretser, David M; Loveland, Katherine A L; O'Bryan, Moira K.

Endocrinology: Adult & Pediatric. ed. / J Larry Jameson; Leslie J De Groot; David M de Kretser; Linda C Giudice; Ashley B Grossman; Shlomo Melmed; John T Potts Jr; Gordon C Weir. Vol. 1 and 2 7th. ed. Philadelphia PA USA : Elsevier, 2016. p. 2325 - 2353.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

TY - CHAP

T1 - Spermatogenesis

AU - de Kretser, David M

AU - Loveland, Katherine A L

AU - O'Bryan, Moira K

PY - 2016

Y1 - 2016

N2 - Spermatogenesis takes place within the seminiferous tubules and involves the replication of stem cells to enable continuous sperm production over the male life span. The process involves mitotic replication of spermatogonia and the subsequent reduction of chromosome number in primary and secondary spermatocytes to the haploid state. The haploid spermatids undergo a complex differentiation process, termed spermiogenesis, resulting in compaction of the nucleus to form the sperm head, the development of the acrosome and sperm tail, a reorganization of the cell organelles, and a shedding of excess cytoplasm. The entire spermatogenic process is highly regulated, and the progression from spermatogonia to sperm takes a fixed duration that differs among species. The only germ cells in contact with the extratubular environment are the spermatogonia. This is because the rest of the germ cell types are lodged within the intratubular immunologically privileged environment controlled by the Sertoli cells that support the developing germ cells structurally and form the blood-testis barrier. The extratubular compartment contains blood vessels that are surrounded by Leydig cells that produce and secrete testosterone, which, together with the gondadotropic hormones FSH and LH, are critical for the production of sperm.

AB - Spermatogenesis takes place within the seminiferous tubules and involves the replication of stem cells to enable continuous sperm production over the male life span. The process involves mitotic replication of spermatogonia and the subsequent reduction of chromosome number in primary and secondary spermatocytes to the haploid state. The haploid spermatids undergo a complex differentiation process, termed spermiogenesis, resulting in compaction of the nucleus to form the sperm head, the development of the acrosome and sperm tail, a reorganization of the cell organelles, and a shedding of excess cytoplasm. The entire spermatogenic process is highly regulated, and the progression from spermatogonia to sperm takes a fixed duration that differs among species. The only germ cells in contact with the extratubular environment are the spermatogonia. This is because the rest of the germ cell types are lodged within the intratubular immunologically privileged environment controlled by the Sertoli cells that support the developing germ cells structurally and form the blood-testis barrier. The extratubular compartment contains blood vessels that are surrounded by Leydig cells that produce and secrete testosterone, which, together with the gondadotropic hormones FSH and LH, are critical for the production of sperm.

UR - http://www.sciencedirect.com/science/book/9780323189071

UR - http://www.elsevierhealth.com.au/endocrinology-adult-and-pediatric-2-volume-set-9780323189071.html

M3 - Chapter (Book)

SN - 9780323189071

VL - 1 and 2

SP - 2325

EP - 2353

BT - Endocrinology

A2 - Jameson, J Larry

A2 - De Groot, Leslie J

A2 - de Kretser, David M

A2 - Giudice, Linda C

A2 - Grossman, Ashley B

A2 - Melmed, Shlomo

A2 - Potts Jr, John T

A2 - Weir, Gordon C

PB - Elsevier

CY - Philadelphia PA USA

ER -

de Kretser DM, Loveland KAL, O'Bryan MK. Spermatogenesis. In Jameson JL, De Groot LJ, de Kretser DM, Giudice LC, Grossman AB, Melmed S, Potts Jr JT, Weir GC, editors, Endocrinology: Adult & Pediatric. 7th ed. Vol. 1 and 2. Philadelphia PA USA: Elsevier. 2016. p. 2325 - 2353