Sperm mitochondria and fertilisation

Justin St John, Emma Bowles, Alexandra Amaral

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

18 Citations (Scopus)

Abstract

Proceedings of the 10th International Symposium on Spermatology, held at El Escorial, Madrid, Spain (17-22 Sept 2006) Human mitochondrial DNA (mtDNA) is an extranuclear genome that encodes 13 of the polypeptides associated with the process of oxidative phosphorylation (OXPHOS). The role and importance of OXPHOS in sperm motiliy and function has been debated over the last few years. Here, we argue that sperm OXPHOS is important to sperm function in the light of clinical based evidence in the human where pathogenic mutations have also been described in sperm and are associated with varying degrees of male subfertility.
Original languageEnglish
Title of host publicationSpermatology
EditorsE R S Roldan, M Gomendio
Place of PublicationUnited Kingdom
PublisherNottingham University Press
Pages399 - 416
Number of pages18
ISBN (Print)9781904761488
Publication statusPublished - 2007
Externally publishedYes

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