Proceedings of the 10th International Symposium on Spermatology, held at El Escorial, Madrid, Spain (17-22 Sept 2006) Human mitochondrial DNA (mtDNA) is an extranuclear genome that encodes 13 of the polypeptides associated with the process of oxidative phosphorylation (OXPHOS). The role and importance of OXPHOS in sperm motiliy and function has been debated over the last few years. Here, we argue that sperm OXPHOS is important to sperm function in the light of clinical based evidence in the human where pathogenic mutations have also been described in sperm and are associated with varying degrees of male subfertility.
|Title of host publication||Spermatology|
|Editors||E R S Roldan, M Gomendio|
|Place of Publication||United Kingdom|
|Publisher||Nottingham University Press|
|Pages||399 - 416|
|Number of pages||18|
|Publication status||Published - 2007|