Speech acoustic markers of early stage and prodromal Huntington's disease: a marker of disease onset?

Adam Vogel, Christopher Shirbin, Andrew J Churchyard, Julie C Stout

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

Speech disturbances (e.g., altered prosody) have been described in symptomatic Huntington s Disease (HD) individuals, however, the extent to which speech changes in gene positive pre-manifest (PreHD) individuals is largely unknown. The speech of individuals carrying the mutant HTT gene is a behavioural/motor/cognitive marker demonstrating some potential as an objective indicator of early HD onset and disease progression. Speech samples were acquired from 30 individuals carrying the mutant HTT gene (13 PreHD, 17 early stage HD) and 15 matched controls. Participants read a passage, produced a monologue and said the days of the week. Data were analysed acoustically for measures of timing, frequency and intensity. There was a clear effect of group across most acoustic measures, so that speech performance differed in-line with disease progression.
Original languageEnglish
Pages (from-to)3273 - 3278
Number of pages6
JournalNeuropsychologia
Volume50
Issue number14
DOIs
Publication statusPublished - 2012

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