Spatially resolved transcriptomics in immersive environments

Denis Bienroth, Hieu T. Nim, Dimitar Garkov, Karsten Klein, Sabrina Jaeger-Honz, Mirana Ramialison, Falk Schreiber

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Spatially resolved transcriptomics is an emerging class of high-throughput technologies that enable biologists to systematically investigate the expression of genes along with spatial information. Upon data acquisition, one major hurdle is the subsequent interpretation and visualization of the datasets acquired. To address this challenge, VR-Cardiomicsis presented, which is a novel data visualization system with interactive functionalities designed to help biologists interpret spatially resolved transcriptomic datasets. By implementing the system in two separate immersive environments, fish tank virtual reality (FTVR) and head-mounted display virtual reality (HMD-VR), biologists can interact with the data in novel ways not previously possible, such as visually exploring the gene expression patterns of an organ, and comparing genes based on their 3D expression profiles. Further, a biologist-driven use-case is presented, in which immersive environments facilitate biologists to explore and compare the heart expression profiles of different genes.

Original languageEnglish
Article number2
Number of pages13
JournalVisual Computing for Industry, Biomedicine, and Art
Volume5
Issue number1
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Fish tank virtual reality
  • Head-mounted display
  • Immersive analytics
  • Immersive environment
  • Spatial transcriptomics
  • Spatially-resolved transcriptomics
  • Virtual reality

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