Spatial memory in Huntington's disease

A comparative review of human and animal data

Yifat Glikmann-Johnston, Kyle D. Fink, Peter Deng, Audrey Torrest, Julie C. Stout

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

To improve the translational predictability of treatment strategies for Huntington's disease (HD), sensitive and analogous cognitive outcomes are needed across HD animal models and humans. Spatial memory measures are promising candidates because they are based on ‘visual’ or ‘non-verbal’ cognition, and are commonly tested in both animals and humans. Here, we consider the suitability of spatial memory for strengthening translational links between animals and humans in HD research and clinical trials. We describe findings of spatial memory impairments in human HD and mouse models, including which aspects of spatial memory are most affected and at which time points in disease progression. We also describe the neural systems that underlie spatial memory and link spatial memory impairments to HD neuropathology, focussing on striatal and hippocampal systems. We provide a critical analysis of the literature in terms of the suitability of spatial memory for bridging the translational gap between species. Finally, we discuss possible neural mechanisms that might explain the spatial memory impairments seen in HD, and their relevance to potential treatments.

Original languageEnglish
Pages (from-to)194-207
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
Volume98
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • HD clinical trials
  • HD mouse models
  • Hippocampus
  • Huntington's disease
  • Spatial memory
  • Striatum
  • Translation

Cite this

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abstract = "To improve the translational predictability of treatment strategies for Huntington's disease (HD), sensitive and analogous cognitive outcomes are needed across HD animal models and humans. Spatial memory measures are promising candidates because they are based on ‘visual’ or ‘non-verbal’ cognition, and are commonly tested in both animals and humans. Here, we consider the suitability of spatial memory for strengthening translational links between animals and humans in HD research and clinical trials. We describe findings of spatial memory impairments in human HD and mouse models, including which aspects of spatial memory are most affected and at which time points in disease progression. We also describe the neural systems that underlie spatial memory and link spatial memory impairments to HD neuropathology, focussing on striatal and hippocampal systems. We provide a critical analysis of the literature in terms of the suitability of spatial memory for bridging the translational gap between species. Finally, we discuss possible neural mechanisms that might explain the spatial memory impairments seen in HD, and their relevance to potential treatments.",
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Spatial memory in Huntington's disease : A comparative review of human and animal data. / Glikmann-Johnston, Yifat; Fink, Kyle D.; Deng, Peter; Torrest, Audrey; Stout, Julie C.

In: Neuroscience and Biobehavioral Reviews, Vol. 98, 01.03.2019, p. 194-207.

Research output: Contribution to journalReview ArticleResearchpeer-review

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