Spark plasma sintering of sol–gel derived 45S5 Bioglass®-ceramics

Mechanical properties and biocompatibility evaluation

Qizhi Chen, Jin Li Xu, Ligen Yu, Xi-Ya Fang, Khiam Khor

Research output: Contribution to journalArticleResearchpeer-review

Abstract

This work aims to find an efficient sintering technique and optimal sintering conditions of a novel sol–gel derived Bioglass®-ceramic powder so as to achieve much improved mechanical properties compared to conventional Bioglass®. To this end, the spark plasma sintering (SPS) technique was for the first time used to densify the sol–gel derived Bioglass®-ceramic powder. It was found that the sol–gel derived Bioglass®-ceramics sintered with the SPS technique at 950 °C for 15 min had a high Young's modulus value of ~ 110 GPa, which was comparable to that of compact bone and significantly higher than the maximal value achieved by the conventional heat treatment. Moreover, the Bioglass®-ceramic compacts sintered with SPS released alkaline ions slowly and as a result, these highly densified Bioglass®-ceramics exhibited better cytocompatibility at the early stage of cell culture testing, compared to the conventional Bioglass®. Hence, the SPS technique is recommended to be used in the process of sol–gel derived Bioglass®-ceramics and its tissue engineering scaffolds.
Original languageEnglish
Pages (from-to)494 - 502
Number of pages9
JournalMaterials Science and Engineering C: Materials for Biological Applications
Volume32
Issue number3
DOIs
Publication statusPublished - 2012

Cite this

@article{0891abc043ce45af917b99c49536ceb7,
title = "Spark plasma sintering of sol–gel derived 45S5 Bioglass{\circledR}-ceramics: Mechanical properties and biocompatibility evaluation",
abstract = "This work aims to find an efficient sintering technique and optimal sintering conditions of a novel sol–gel derived Bioglass{\circledR}-ceramic powder so as to achieve much improved mechanical properties compared to conventional Bioglass{\circledR}. To this end, the spark plasma sintering (SPS) technique was for the first time used to densify the sol–gel derived Bioglass{\circledR}-ceramic powder. It was found that the sol–gel derived Bioglass{\circledR}-ceramics sintered with the SPS technique at 950 °C for 15 min had a high Young's modulus value of ~ 110 GPa, which was comparable to that of compact bone and significantly higher than the maximal value achieved by the conventional heat treatment. Moreover, the Bioglass{\circledR}-ceramic compacts sintered with SPS released alkaline ions slowly and as a result, these highly densified Bioglass{\circledR}-ceramics exhibited better cytocompatibility at the early stage of cell culture testing, compared to the conventional Bioglass{\circledR}. Hence, the SPS technique is recommended to be used in the process of sol–gel derived Bioglass{\circledR}-ceramics and its tissue engineering scaffolds.",
author = "Qizhi Chen and Xu, {Jin Li} and Ligen Yu and Xi-Ya Fang and Khiam Khor",
year = "2012",
doi = "10.1016/j.msec.2011.11.023",
language = "English",
volume = "32",
pages = "494 -- 502",
journal = "Materials Science and Engineering C: Materials for Biological Applications",
issn = "0928-4931",
publisher = "Elsevier",
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}

Spark plasma sintering of sol–gel derived 45S5 Bioglass®-ceramics : Mechanical properties and biocompatibility evaluation. / Chen, Qizhi; Xu, Jin Li; Yu, Ligen; Fang, Xi-Ya; Khor, Khiam.

In: Materials Science and Engineering C: Materials for Biological Applications, Vol. 32, No. 3, 2012, p. 494 - 502.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Spark plasma sintering of sol–gel derived 45S5 Bioglass®-ceramics

T2 - Mechanical properties and biocompatibility evaluation

AU - Chen, Qizhi

AU - Xu, Jin Li

AU - Yu, Ligen

AU - Fang, Xi-Ya

AU - Khor, Khiam

PY - 2012

Y1 - 2012

N2 - This work aims to find an efficient sintering technique and optimal sintering conditions of a novel sol–gel derived Bioglass®-ceramic powder so as to achieve much improved mechanical properties compared to conventional Bioglass®. To this end, the spark plasma sintering (SPS) technique was for the first time used to densify the sol–gel derived Bioglass®-ceramic powder. It was found that the sol–gel derived Bioglass®-ceramics sintered with the SPS technique at 950 °C for 15 min had a high Young's modulus value of ~ 110 GPa, which was comparable to that of compact bone and significantly higher than the maximal value achieved by the conventional heat treatment. Moreover, the Bioglass®-ceramic compacts sintered with SPS released alkaline ions slowly and as a result, these highly densified Bioglass®-ceramics exhibited better cytocompatibility at the early stage of cell culture testing, compared to the conventional Bioglass®. Hence, the SPS technique is recommended to be used in the process of sol–gel derived Bioglass®-ceramics and its tissue engineering scaffolds.

AB - This work aims to find an efficient sintering technique and optimal sintering conditions of a novel sol–gel derived Bioglass®-ceramic powder so as to achieve much improved mechanical properties compared to conventional Bioglass®. To this end, the spark plasma sintering (SPS) technique was for the first time used to densify the sol–gel derived Bioglass®-ceramic powder. It was found that the sol–gel derived Bioglass®-ceramics sintered with the SPS technique at 950 °C for 15 min had a high Young's modulus value of ~ 110 GPa, which was comparable to that of compact bone and significantly higher than the maximal value achieved by the conventional heat treatment. Moreover, the Bioglass®-ceramic compacts sintered with SPS released alkaline ions slowly and as a result, these highly densified Bioglass®-ceramics exhibited better cytocompatibility at the early stage of cell culture testing, compared to the conventional Bioglass®. Hence, the SPS technique is recommended to be used in the process of sol–gel derived Bioglass®-ceramics and its tissue engineering scaffolds.

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DO - 10.1016/j.msec.2011.11.023

M3 - Article

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JO - Materials Science and Engineering C: Materials for Biological Applications

JF - Materials Science and Engineering C: Materials for Biological Applications

SN - 0928-4931

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