SOX13 exhibits a distinct spatial and temporal expression pattern during chondrogenesis, neurogenesis, and limb development

Yi Wang, Sika Ristevski, Vincent R. Harley

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

SOX13 is a member of the SOX family of transcription factors. SOX proteins play essential roles in development, and some are associated with human genetic diseases. SOX13 maps to a multi-disease locus on chromosome 1q31-32, yet its function is unknown. Here we describe the temporal and spatial expression of SOX13 protein during mouse organogenesis. SOX13 is expressed in the three embryonic cell lineages, suggesting that it may direct various developmental processes. SOX13 is expressed in the developing central nervous system including the neural tube and the developing brain. Expression is also detected in the condensing mesenchyme and cartilage progenitor cells during endochondral bone formation in the limb as well as the somite sclerotome and its derivatives. SOX13 is also detected in the developing kidney, pancreas, and liver as well as in the visceral mesoderm of the extra-embryonic yolk sac and spongiotrophoblast layer of the placenta.

Original languageEnglish
Pages (from-to)1327-1333
Number of pages7
JournalJournal of Histochemistry and Cytochemistry
Volume54
Issue number12
DOIs
Publication statusPublished - 1 Dec 2006
Externally publishedYes

Keywords

  • Endochondral bone
  • Expression pattern
  • Mouse embryonic development
  • Neural tube
  • Sclerotome
  • SOX13
  • Spongiotrophoblast
  • Visceral mesoderm

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