Sorption of chlormethiazole by intravenous infusion giving sets

S. E. Tsuei, R. L. Nation, J. Thomas

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The sorption of chlormethiazole by intravenous infusion giving sets was investigated. Average recoveries of chlormethiazole following 500 ml infusions were 78.5%, 82.2% and 71.2% for the IVAC Volume Infusion Set, Travenol Code AHC 2890 Blood Administration Set and the McGaw Metriset, respectively. The effluent concentration-time profile using set up procedures and infusion rates similar to those used clinically were followed. When compared to solutions flowing at an infusion rate of 75 and 150 ml/h, loss of chlormethiazole from solutions standing static in the influsion sets was higher while that of solutions flowing at a high rate of 999 ml/h was lower. The clinical and pharmacokinetic significance of these phenomena are discussed.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalEuropean Journal of Clinical Pharmacology
Volume18
Issue number4
DOIs
Publication statusPublished - 1 Jul 1980

Keywords

  • chlormethiazole
  • giving sets
  • sorption by infusion

Cite this

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Sorption of chlormethiazole by intravenous infusion giving sets. / Tsuei, S. E.; Nation, R. L.; Thomas, J.

In: European Journal of Clinical Pharmacology, Vol. 18, No. 4, 01.07.1980, p. 333-338.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Sorption of chlormethiazole by intravenous infusion giving sets

AU - Tsuei, S. E.

AU - Nation, R. L.

AU - Thomas, J.

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N2 - The sorption of chlormethiazole by intravenous infusion giving sets was investigated. Average recoveries of chlormethiazole following 500 ml infusions were 78.5%, 82.2% and 71.2% for the IVAC Volume Infusion Set, Travenol Code AHC 2890 Blood Administration Set and the McGaw Metriset, respectively. The effluent concentration-time profile using set up procedures and infusion rates similar to those used clinically were followed. When compared to solutions flowing at an infusion rate of 75 and 150 ml/h, loss of chlormethiazole from solutions standing static in the influsion sets was higher while that of solutions flowing at a high rate of 999 ml/h was lower. The clinical and pharmacokinetic significance of these phenomena are discussed.

AB - The sorption of chlormethiazole by intravenous infusion giving sets was investigated. Average recoveries of chlormethiazole following 500 ml infusions were 78.5%, 82.2% and 71.2% for the IVAC Volume Infusion Set, Travenol Code AHC 2890 Blood Administration Set and the McGaw Metriset, respectively. The effluent concentration-time profile using set up procedures and infusion rates similar to those used clinically were followed. When compared to solutions flowing at an infusion rate of 75 and 150 ml/h, loss of chlormethiazole from solutions standing static in the influsion sets was higher while that of solutions flowing at a high rate of 999 ml/h was lower. The clinical and pharmacokinetic significance of these phenomena are discussed.

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