Sonochemical protocols for Grignard reactions

Sergei A. Smolnikov; Muhammad Syafiq Shahari; Anton V. Dolzhenko

doi:10.1016/B978-0-12-819540-6.00009-7

Sonochemical protocols for Grignard reactions

Sergei A. Smolnikov, Muhammad Syafiq Shahari, Anton V. Dolzhenko

Malaysia Sch of Pharmacy

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

3 Citations (Scopus)

Abstract

Grignard reagents have been known for more than a hundred years as tools to create new carbon-carbon bonds. The preparation of Grignard reagents and their reactions with carbonyl compounds (Grignard reaction) under ultrasound irradiation are discussed in this chapter. While ultrasound has proven to be efficient for the activation of magnesium surface and facilitation of the preparation of Grignard reagents, benefits of sonication in the Grignard reaction remain unclear and the outcome strongly depends on the substrate structure. The specific parameters of ultrasound irradiation also appear to play an important role in the synthesis and subsequent reactions of Grignard reagents.

Original language	English
Title of host publication	Green Sustainable Process for Chemical and Environmental Engineering and Science
Subtitle of host publication	Sonochemical Organic Synthesis
Editors	Inamuddin, Rajender Boddula, Abdulah M. Asiri
Place of Publication	Amsterdam Netherlands
Publisher	Elsevier
Chapter	9
Pages	243-255
Number of pages	13
Edition	1st
ISBN (Print)	9780128195406
DOIs	https://doi.org/10.1016/B978-0-12-819540-6.00009-7
Publication status	Published - 2020

Keywords

Barbier reaction
Carbonyl compounds
Grignard reaction
Grignard reagents
Magnesium
Organometallic sonochemistry
Radical reaction
Sonication
Ultrasound

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10.1016/B978-0-12-819540-6.00009-7

Cite this

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abstract = "Grignard reagents have been known for more than a hundred years as tools to create new carbon-carbon bonds. The preparation of Grignard reagents and their reactions with carbonyl compounds (Grignard reaction) under ultrasound irradiation are discussed in this chapter. While ultrasound has proven to be efficient for the activation of magnesium surface and facilitation of the preparation of Grignard reagents, benefits of sonication in the Grignard reaction remain unclear and the outcome strongly depends on the substrate structure. The specific parameters of ultrasound irradiation also appear to play an important role in the synthesis and subsequent reactions of Grignard reagents.",

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Sonochemical protocols for Grignard reactions. / Smolnikov, Sergei A.; Shahari, Muhammad Syafiq; Dolzhenko, Anton V.
Green Sustainable Process for Chemical and Environmental Engineering and Science: Sonochemical Organic Synthesis. ed. / Inamuddin; Rajender Boddula; Abdulah M. Asiri. 1st. ed. Amsterdam Netherlands: Elsevier, 2020. p. 243-255.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

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T1 - Sonochemical protocols for Grignard reactions

AU - Smolnikov, Sergei A.

AU - Shahari, Muhammad Syafiq

AU - Dolzhenko, Anton V.

PY - 2020

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KW - Carbonyl compounds

KW - Grignard reaction

KW - Grignard reagents

KW - Magnesium

KW - Organometallic sonochemistry

KW - Radical reaction

KW - Sonication

KW - Ultrasound

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PB - Elsevier

CY - Amsterdam Netherlands

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Sonochemical protocols for Grignard reactions

Abstract

Keywords

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