Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

M. G. Hinds; R. S. Norton; D. L. Vaux; C. L. Day

doi:10.1038/10701

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

M. G. Hinds, R. S. Norton, D. L. Vaux, C. L. Day

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158 Citations (Scopus)

Abstract

Members of the inhibitor of apoptosis (IAP) family of proteins are able to inhibit cell death following viral infection, during development or in cell lines in vitro. All IAP proteins bear one or more baculoviral IAP repeats (BIRs). Here we describe the solution structure of the third BIR domain from the mammalian IAP homolog B (MIHB/c- IAP-1). The BIR domain has a novel fold that is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues. The structure consists of a series of short α-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs.

Original language	English
Pages (from-to)	648-651
Number of pages	4
Journal	Nature Structural Biology
Volume	6
Issue number	7
DOIs	https://doi.org/10.1038/10701
Publication status	Published - 1999
Externally published	Yes

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abstract = "Members of the inhibitor of apoptosis (IAP) family of proteins are able to inhibit cell death following viral infection, during development or in cell lines in vitro. All IAP proteins bear one or more baculoviral IAP repeats (BIRs). Here we describe the solution structure of the third BIR domain from the mammalian IAP homolog B (MIHB/c- IAP-1). The BIR domain has a novel fold that is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues. The structure consists of a series of short α-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs.",

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Y1 - 1999

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AB - Members of the inhibitor of apoptosis (IAP) family of proteins are able to inhibit cell death following viral infection, during development or in cell lines in vitro. All IAP proteins bear one or more baculoviral IAP repeats (BIRs). Here we describe the solution structure of the third BIR domain from the mammalian IAP homolog B (MIHB/c- IAP-1). The BIR domain has a novel fold that is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues. The structure consists of a series of short α-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs.

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Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

Abstract

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